HBV持续感染及其机制的研究进展  

Research advances in persistent hepatitis B virus infection and its mechanism

作　　者：陈欢 杨燕卿 储君 张国远 林世德 CHEN Huan;YANG Yanqing;CHU Jun(Department of Infectious Diseases,The Affiliated Hospital of Zunyi Medical University,Zu nyi,Guizhou 563003,China)

机构地区：[1]遵义医科大学附属医院感染科

出　　处：《临床肝胆病杂志》2020年第1期174-177,共4页Journal of Clinical Hepatology

基　　金：国家自然科学基金(814600124/H0316)

摘　　要：HBV属嗜肝DNA病毒科,可引起人类急性和慢性肝炎,甚至肝硬化、肝癌。目前的抗病毒药物因不能彻底清除肝细胞内HBV,故很难达到治愈的效果。近年来,HBV持续感染的机制受到广泛关注,主要涉及宿主与病毒两方面,从病毒方面展开,主要阐述了cccDNA、HBV颗粒和HBV自身组分维持HBV持续感染的相关研究进展。Hepatitis B virus(HBV) belongs to the Hepadnaviridae family and can cause acute and chronic hepatitis,liver cirrhosis,and even liver cancer in humans. Current antiviral drugs cannot completely eliminate HBV in liver cells and thus it is difficult to achieve a curative effect. In recent years,the mechanism of persistent HBV infection has attracted wide attention,which mainly involves host and virus. This article elaborates on the research advances in persistent HBV infection from the aspect of virus,including covalently closed circular DNA,HBV particles,and HBV components.

关 键 词：乙型肝炎病毒 乙型肝炎表面抗原 乙型肝炎E抗原 乙型肝炎核心抗原 DNA 环状 

分 类 号：R512.62[医药卫生—内科学]