细胞焦亡研究进展  

Research progress of pyroptosis

作　　者：黄清宇 杜楚江 张雨竹 曹宏伟 郝慧芳[1] HUANG Qing-Yu;DU Chu-Jiang;ZHANG Yu-Zhu;CAO Hong-Wei;HAO Hui-Fang(College of Life Sciences of Inner Mongolia University,Hohhot 010021,China)

机构地区：[1]内蒙古大学生命科学学院

出　　处：《中国免疫学杂志》2020年第2期245-250,共6页Chinese Journal of Immunology

基　　金：国家自然科学基金项目(No.31860309,31760675);内蒙古自治区自然科学基金博士基金项目(No.2016BS0304);内蒙古自治区留学归国人员启动项目(No.12000-12101014);内蒙古大学高层次人才引进科研项目(No.135130)资助

摘　　要：细胞焦亡是一种新发现的依赖于Gasdermin蛋白家族成孔活性的细胞程序性炎症坏死,在抵抗外部病原体入侵和感知内源危险信号中发挥着不可替代的作用,其形态学特征、发生及作用机制与细胞凋亡等典型细胞死亡方式有显著不同。焦亡由炎症小体激活Caspase-1的经典细胞焦亡途径和胞质LPS激活Caspase-4/5/11的非经典细胞焦亡途径而诱发。本文就近年来细胞焦亡的发现和命名、形态学和分子特征、分子机制和焦亡相关的疾病进行综述,为疾病预防诊断及临床药物的靶向治疗提供理论依据和现实的可行性。Pyroptosis is a newly discovered programmed inflammatory necrosis that depends on the pore-forming activity of the gasdermin protein family.Pyroptosis plays a key role in detecting and responding to intracellular pathogens.The morphological and molecular determinants of pyroptosis are significantly different from other patterns of characteristic cell death such as apoptosis.The activation pathways of pyroptosis are divided into the canonical pyroptosis pathway in which inflammatory activate caspase-1 and the noncanonical pyroptosis pathway in which cytosolic LPS activates caspase-4/5/11.In this paper,the discovery and naming,morphological and molecular characteristics,molecular mechanisms of pyroptosis and diseases associated with pyroptosis in recent years are reviewed,which provides theoretical basis and realistic feasibility for disease prevention and targeted therapy of clinical drugs.

关 键 词：程序性细胞死亡 细胞焦亡 炎性小体 Gasdermin D 

分 类 号：R392.12[医药卫生—免疫学]