海洛因成瘾者大脑中心度变化特征的静息态功能MRI研究  

Altered degree centrality in heroin addicts:a rs-fMRI study

作　　者：代晓峰 胡风 王磊 王玮 魏龙晓 王亚蓉 DAI Xiaofeng;HU Feng;WANG Lei;WANG Wei;WEI Longriao;WANG Yarong(Depariment of Nuclear Medicine,Tangdu Hospital,the Air Force Military Medical University,Xi'an 710038,China;Department of Radiology,96604 Military Hospital of PLA,Lanzhou 730030,China;Department of Radiology,the First Affiliated Hospital of Xi'an Jiaotong University,Xi'an 710061,China)

机构地区：[1]空军军医大学唐都医院核医学科,陕西西安710038 [2]中国人民解放军,96604部队医院医学影像科,甘肃兰州730030 [3]西安交通大学第一附属医院医学影像科,陕西西安710061

出　　处：《实用放射学杂志》2020年第1期1-4,共4页Journal of Practical Radiology

基　　金：国家自然科学基金项目(81471648)。

摘　　要：目的探讨海洛因成瘾者(HA)体素水平脑网络中心度(DC)的变化特点,并分析其与海洛因使用总量的相关关系.方法纳入37例HA为病例组和33例健康被试(HC)为对照组,采用3.0T MR对被试进行大脑rs-fMRI扫描,数据经后处理软件(dpabi)校正分析,获得HA组和HC组大脑DC差异图,并对差异DC脑区信号强度与患者使用海洛因总量进行偏相关性分析.结果与HC组相比,HA组双侧丘脑,右侧尾状核、右侧壳核,左侧脑岛、左侧背外侧前额叶、左侧中央前回DC值明显降低;双侧楔前叶、右侧顶上回以及左侧小脑第八区显著增高(P<0.001,最小体素>20,Alphasim校正).其中,右尾状核DC值与患者海洛因使用总量负相关(r=-0.391,P=0.017).结论HA大脑网络中背侧纹状体、抑制性控制环路、内感受中心脑区的重要节点脑区活动性下降;成瘾习惯行为的形成与吸毒总量呈正性相关.Objective To explore the characteristics of degree centrality(DC)in heroin addicts(HA)brain network in the voxel level and to analyze the correlation between them and the total amount of heroin consumption.Methods 37 HA were enrolled into the case group and 33 healthy control(HC)were recruited into the control group.rs-fMRI data was collected using a 3.0T MR scanner.The data was corrected by post processing software(dpabi)to obtain brain DC difference in HA and HC groups.The partial correlation was performed between the signal intensity within different DC brain areas and the total amount of heroin consumption.Results Compared with the HC group,HA had a significantly decreased DC in the bilateral thalamus,right caudate,right putamen,left insula,left dorsal lateral prefrontal cortex,left precentral gyrus and increased DC in the bilateral precuneus,right parietal gyrus and cerebellum-8 area(P<0.001,voxel size>20,Alphasim correction).Meanwhile,there was a negative correction between the DC value of the right caudate and the accumulated heroin consumption(r=-0.391,P=0.017).Conclusion For HA,activity of important nodes in the dorsal striatum circuitry,the inhibitory control circuitry as well as interoceptive system showed decline;The formation of addiction habits is positively related to the total amount of heroin consumption.

关 键 词：海洛因 成瘾 中心度 功能磁共振成像 

分 类 号：R996[医药卫生—毒理学] R322.81[医药卫生—药学]