丹参酮ⅡA磺酸钠对ARDS患者IL-6、IL-8、TNF-α及sICAM-1炎症因子的干预作用研究  

Interventional effect of sodium tanshinoneⅡA silate on inflammatory factors of IL-6,IL-8,TNF-α and sICAM-1 in ARDS patients

作　　者：曹珊 张湘燕[1] 张程[1] 林洁如[1] 许梅[1] CAO Shan;ZHANG Xiangyan;ZHANG Cheng;LIN Jieru;XU Mei(Department of Respiratory and Critical Diseases,Guizhou Provincial People's Hospital,Guiyang,Guizhou,550001,China)

机构地区：[1]贵州省人民医院呼吸与危重症学科

出　　处：《现代医药卫生》2020年第5期644-646,650,共4页Journal of Modern Medicine & Health

基　　金：贵州省科技厅科技攻关项目(2003JW025);贵州省贵阳市科技厅科技计划项目(筑科合同〔20151001〕社54号)

摘　　要：目的探讨急性呼吸窘迫综合征(ARDS)患者在丹参酮ⅡA磺酸钠干预下常见炎症因子水平变化。方法收集贵州省人民医院2016-2017年呼吸重症监护病房(RICU)及急诊重症监护病房(EICU)的ARDS患者(治疗时间大于7 d)40例作为研究对象,将其分为基础治疗组(A组)、丹参酮ⅡA磺酸钠干预+基础治疗组(B组),并均采集治疗前后患者血清,检测白细胞介素6(IL-6)、IL-8、肿瘤坏死因子-α(TNF-α)、可溶性细胞间黏附分子-1(sICAM-1)水平,计算氧合指数。结果(1)A、B组治疗后TNF-α、IL-6、sICAM-1水平均显著低于治疗前(P<0.05);氧合指数均较治疗前升高(P<0.05);(2)B组治疗后TNF-α、IL-6、sICAM-1水平均显著低于A组(P<0.05),且氧合改善程度更优于A组(P<0.05);(3)A、B组治疗后IL-8水平比较,差异无统计学意义(P>0.05)。结论将丹参酮ⅡA磺酸加入ARDS患者治疗方案中可以进一步降低血清中TNF-α、IL-6、sICAM-1水平,同时改善氧合指数。ARDS患者血清中IL-8水平不能被丹参酮ⅡA磺酸钠干预。Objective To investigate the changes of common inflammatory factors in the patients with acute respiratory distress syndrome(ARDS)under the intervention of sodium tanshinoneⅡA silate by comparing the changes of oxygenation index and common inflammatory factors concentrations in serum before and after treatment.Methods Forty cases of ARDS(treatment time>7 d)in the Respiratory Intensive Care Unit(RICU)and the Emergency Intensive Care Units(EICU)of the Guizhou Provincial People's Hospital during 2016-2017 were collected as the study subjects and divided into the basic treatment group(group A),sodium tanshinoneⅡA silate intervention+basic treatment group(group B).The serum was collected before and after treatment.The concentrations of interleukin-6(IL-6),IL-8,tumor necrosis factor-α(TNF-α)and intercellular adhesion molecule-1(sICAM-1)were detected.The oxygenation index was calculated.Results(1)The concentrations of TNF-α,IL-6 and ICAM-1 after treatment in the group A and group B were significantly lower than those before treatment(P<0.05);the oxygenation index was increased compared with before treatment(P<0.05);(2)The concentrations of TNF-α,IL-6 and sICAM-1 after treatment in the group B were significantly lower than those in the group A(P<0.05),moreover the improvement degree of oxygenation index was better than that in the group(P<0.05).(3)There was no statistically significant difference in the concentration of IL-8 after treatment between group A and B(P>0.05).Conclusion Adding sodium tanshinoneⅡA silate into the therapeutical scheme of the patients with ARDS can further reduce the concentrations of serum TNF-α,IL-6 and sICAM-1 and simultaneously improve the oxygenation index.The concentration of IL-8 in the patients with ARDS can not be interfered by sodium tanshinoneⅡA silate.

关 键 词：炎症因子 氧合指数 丹参酮ⅡA磺酸钠 急性呼吸窘迫综合征 可溶性细胞间黏附分子-1 

分 类 号：R563[医药卫生—呼吸系统]