黄芪饮片及配方颗粒中黄芪甲苷与毛蕊异黄酮葡萄糖苷的含量测定  

Determination of Astragaloside IV and Isoflavone Glucosides in Huangqi Decoction Tablets and Formula Granules

作　　者：齐静静 QI Jingjing(Department of Pharmacy,Yingkou Hospital of Traditional Chinese Medicine,Liaoning Province,Yingkou 115000,China)

机构地区：[1]营口市中医院药剂科

出　　处：《中国中医药现代远程教育》2020年第3期107-109,共3页Chinese Medicine Modern Distance Education of China

摘　　要：目的实验分析黄芪饮片及配方颗粒中黄芪甲苷与毛蕊异黄酮葡萄糖苷的含量测定。方法将黄芪甲苷与毛蕊异黄酮葡萄糖苷含量作为评价指标,经由Waters高效液相色谱仪测定黄芪饮片及配方颗粒中成份含量和不同环境下的稳定性。结果黄芪饮片中的黄芪甲苷含量低于黄芪配方颗粒,毛蕊异黄酮葡萄糖苷含量高于黄芪配方颗粒,但对比无明显差异(P>0.05);加速实验测定显示40℃、75%RH环境下,黄芪饮片及配方颗粒中黄芪甲苷与毛蕊异黄酮葡萄糖苷含量无明显变化,对比无明显差异(P>0.05);高温、高湿、强光条件下配方颗粒中的毛蕊异黄酮葡萄糖苷含量变化明显,同条件下黄芪饮片中黄芪甲苷含量变化更为明显。结论综合有效成份和制剂稳定性,黄芪配方颗粒可替代黄芪饮片,本次试验可为配方颗粒统一工艺标准和质量标准提供参考。Objective To determine the content of astragaloside IV and flavonoid glucoside in Huangqi decoction tablets and formula granules.Methods The content of astragaloside IV and isoflavone glucoside was used as an evaluation index.The content of components in Huangqi decoction pieces and formula granules and the stability under different environments were determined by Waters high performance liquid chromatography.Results The content of astragaloside IV in Huangqi decoction tablets was lower than that in Huangqi formula.The content of glucosides of isoflavones was higher than that of Huangqi formula,but there was no significant difference(P>0.05).Accelerated test showed 40℃ and 75%RH.There was no significant difference in the content of astragaloside IV and isoflavone glucoside in Huangqi decoction tablets and formula granules.There was no significant difference(P>0.05).The content of flavonoids in the granules of the formula was significantly changed under high temperature,high humidity and strong light.Under the same conditions,the content of astragaloside Ⅳ in Huangqi decoction tablets is more obvious.Conclusion The comprehensive effective ingredients and preparation stability,Astragalus formula particles can replace Huangqi decoction pieces,this test can provide reference for the unified process standards and quality standards of formula particles.

关 键 词：黄芪饮片 配方颗粒 黄芪甲苷 毛蕊异黄酮葡萄糖苷 

分 类 号：R286.0[医药卫生—中药学]