TRPV5与TRPV6在哺乳动物妊娠期钙代谢的适应性调节作用  

The Role of TRPV5 and TRPV6 on Animal Maternal Adaptations of Calcium Metabolism

作　　者：季佳 马真明 和塍 朱畅荣 周文君 黄小兰 李佳佳 李素华 JI Jia;MA Zhenming;HE Chen;ZHU Changrong;ZHOU Wenjun;HUANG Xiaolan;LI Jiajia;LI Suhua(College of Life Sciences,Southwest Forestry University,Kunming 650224,China;Animal Husbandry Department of Xundian Sub-district Office,Kunming 655200,China;Nujiang Animal Disease Prevention and Control Center,Nujiang 673200,China;Xishuangbanna Animal Disease Prevention and Control Center,Xishuangbanna 666100,China;Qilu Animal Health Products Limited Company,Jinan 250000,China)

机构地区：[1]西南林业大学生命科学学院,云南昆明650224 [2]云南省寻甸县塘子街道办事处畜牧科,云南昆明655200 [3]云南省怒江州动物疫病预防控制中心,云南怒江673200 [4]云南省西双版纳州动物疫病预防控制中心,云南西双版纳666100 [5]齐鲁动物保健品有限公司,山东济南250000

出　　处：《中国猪业》2020年第1期46-49,52,共5页China Swine Industry

基　　金：国家自然科学基金项目(31260630)

摘　　要：在哺乳动物妊娠期,母体的钙代谢通过适应性调节满足胎儿对钙的需求,包括肠钙吸收的增强、肾钙排泄的减少。妊娠钙代谢适应性需要钙离子通路蛋白参与,TRPV5/TRPV6是实现钙代谢调节的重要蛋白。TRPV6高表达于小肠,主要介导肠钙转运,TRPV5与肾脏钙离子重吸收相关,此外TRPV6介导胎盘组织的母体一胎儿钙转运。Calcium demands would lead to maternal adaptations to fit the changes in calcium requirement during pregnancy.Such adaptation involves the increase of intestinal calcium absorption and decrease of renal calcium excretion.TRPV5 and TRPV6 serving as the gatekeepers of transepithelial Ca2+transport is involved in the maternal-fetal Ca2+transport of mammals.TRPV6 protein predominantly expresses at intestinal and TRPV5 mainly in kidney.Furthermore,TRPV6 is thought to play an important role in maternal-fetal calcium transport in placental tissue.

关 键 词：钙代谢 TRPV5 TRPV6 妊娠 适应性 

分 类 号：S828[农业科学—畜牧学] S816.7[农业科学—畜牧兽医]