芪山无糖颗粒治疗湿热困脾证初发2型糖尿病随机对照研究  

Clinical Study of Qishan Sugar-free Granules in the Treatment of Primary Type 2 Diabetes Patients with Heat and Dampness Syndrome:A Randomized Controlled Trial

作　　者：朱岚[1] 魏燕[1] 金剑虹[1] 叶迅[1] 徐新鹏[1] 洪郁芝[1] ZHU Lan;WEI Yan;JIN Jianhong;YE Xun;XU Xin-peng;HONG Yu-zhi(Department of Endocrinology,Hangzhou Hospital of Traditional Chinese Medicine,Hangzhou,310007)

机构地区：[1]杭州市中医院内分泌科

出　　处：《中国中西医结合杂志》2020年第2期154-157,共4页Chinese Journal of Integrated Traditional and Western Medicine

基　　金：2015年杭州市科委引导项目(No.2015KJJ-018)

摘　　要：目的观察芪山无糖颗粒治疗湿热困脾证初诊2型糖尿病的疗效。方法采用随机对照法,将湿热困脾证初诊2型糖尿病60例患者随机数字表法分为治疗组和对照组,每组30例。对照组口服盐酸二甲双胍片500 mg/次,每日3次;治疗组予芪山无糖颗粒,每次1小包,每日2次,治疗观察6个月。治疗前和治疗3、6个月时检测患者糖化血红蛋白(HbA1c)、空腹血糖(FPG)、空腹血浆胰岛素(FINS),计算胰岛素抵抗指数(HOMA-IR)。同时检测尿酸(UA)、低密度脂蛋白(LDL-C),测量腰围和体重及炎性因子:尿白蛋白(A)/肌酐(C)比值,C反应蛋白(CRP)、同型半胱氨酸(HCY)。结果与本组治疗前比较,两组患者治疗3、6个月HbA1c、FPG、HOMA-IR、LDL-C、UA、腰围、HCY、CRP、尿A/C比值降低(P<0.05)。与本组治疗3个月比较,两组UA、LDL-C、腰围均降低(P<0.05),治疗组患者治疗6个月CRP、HCY、尿A/C比值水平降低(P<0.05);对照组患者治疗6个月HCY、尿A/C比值水平降低(P<0.05),但CRP差异无统计学意义(P>0.05)。与对照组比较,治疗组治疗3个月及6个月腰围、CRP、尿A/C比值降低(P<0.05)。结论芪山无糖颗粒治疗湿热困脾证型初诊2型糖尿病降糖有效,并且降糖疗效与二甲双胍相当,而且在减少腰围、改善炎性因子、改善尿微量蛋白等方面具有更好作用。Objective To observe the clinical curative effect of Qishan Sugar-free Granules in the treatment of primary type 2 diabetes patients with heat and dampness syndrome.Methods A randomized controlled study was conducted,60 type 2 diabetes patients with heat and dampness syndrome were assigned to treatment group(30 cases)and control group(30 cases)according to random number table.The control group was given oral metformin hydrochloride 500 mg,1 pack each time,3 times a day.The treatment group was given Qishan Sugar-free Granules,2 times a day.All course was 6 months.Glycosylated hemoglobin A1c(HbA1c),fasting blood glucose(FBG),fasting insulin(FINS),the calculation of insulin resistance index(HOMA-IR),uric acid(UA),low density lipoprotein-cholesterol(LDL-C),waist,weight,urine protein creatinine ratio(ACR),C reactive protein(CRP)and homocysteine(HCY)were determined and recorded at baseline and after 3 and 6 months of treatment.Results Compared with the baseline,after the 3 and 6 months treatment,HbA1c,FBG,HOMA-IR,UA,LDL-C,waist,ACR,CRP and HCY decreased in both groups(P<0.05).Compared with after 3 months treatment,UA,LDL-C,waist,ACR,and HCY levels decreased in both groups after 6 months treatment(P<0.05),while CRP levels decreased only in treatment group(P<0.05).Compared with the control group,the difference of waist,CRP and ACR were statistically decreased in treatment group after 3 and 6 months treatment(P<0.05).Conclusions The clinical curative effect of Qishan Sugar-free Granules in the treatment of primary type 2 diabetes with heat and dampness syndrome is as good as metformin in glucose control.And it improve better at the loss of waist,ACR and the inflammatory factor such as CRP.

关 键 词：2型糖尿病 湿热困脾证 芪山无糖颗粒 二甲双胍 

分 类 号：R259[医药卫生—中西医结合]