不同剂量帕洛诺司琼预防恶心呕吐的临床疗效对比  

Comparison of Clinical Efficacy of Different Doses of Palonosetron in Preventing Nausea and Vomiting

作　　者：孙小英 顾礼萍 徐贤惠 徐美云 Xiaoying Sun;Liping Gu;Xianhui Xu;Meiyun Xu(Yangzhong Traditional Chinese Medicine Hospital,Yangzhong,Jiangsu,212200,China)

机构地区：[1]扬中市中医院,中国江苏扬中212200

出　　处：《亚洲临床医学杂志》2019年第5期19-21,共3页Asian Journal of Clinical Medicine

摘　　要：目的:观察不同剂量帕洛诺司琼预防内镜检查和治疗后恶心呕吐的临床疗效。方法:选择2018.1月-2018.12月间在我院行内镜检查与治疗的101例患者,采用电脑随机法将其划分为3组,分别为A组33例、B组34例、C组34例,于麻醉诱导前静脉注射不同剂量帕洛诺司琼,其中A组给予帕洛诺司琼0.0375mg、B组给予0.075mg、C组给予0.15mg;评估3组患者术后0-12h、12-24h、24-48h、恶心呕吐发生情况。结果:C组患者术后各个时间段内恶心、呕吐发生率均低于A组与B组,结果具有统计学意义,P<0.05。结论:给予帕洛诺司琼0.15mg显著减少术后恶心呕吐发生率,能够有效预防内镜检查和治疗后恶心呕吐并发症。Objective:To observe the clinical efficacy of different doses of palonosetron in preventing nausea and vomiting after endoscopy and treatment.Methods:A total of 101 patients who underwent endoscopic examination and treatment in our hospital from January 2018 to December 2018 were selected and divided into 3 groups by computer random method,which were 33 cases in group A,34 cases in group B,and 34 cases in group C.Before the induction of anesthesia,different doses of palonosetron were injected intravenously,in which group A received 0.0375 mg of palonosetron,group B received 0.075 mg,and group C received 0.15 mg.-24h,24-48h,nausea and vomiting.Results:The incidence of nausea and vomiting in patients in group C was lower than that in group A and group B in all time periods.The results were statistically significant,P<0.05.Conclusion:The administration of Palonosetron 0.15mg can significantly reduce the incidence of postoperative nausea and vomiting,and can effectively prevent the complications of nausea and vomiting after endoscopy and treatment.

关 键 词：帕洛诺司琼 内镜检查 恶心 呕吐 剂量 并发症 手术 5-HT3受体拮抗剂 

分 类 号：R47[医药卫生—护理学]