亚临床甲减孕妇的胎儿超声特征分析  

Analysis of fetal ultrasound characteristics of pregnant women with subclinical hypothyroidism

作　　者：朱晓青 赵丽燕 丁延华 张丽丹 高建松 金菊 施晓春 ZHU Xiao-qin;ZHAO Liyan;DING Yanhua;ZHANG Lidan;GAO Jiansong;JIN Ju;SHI Xiaochun(Department of Ultrasound,Hangzhou Women′s Hospital,Hangzhou 310006,Zhejiang,China;Obstetrics Department,Hangzhou Women′s Hospital,Hangzhou 310006,Zhejiang,China;Laboratory Department,Hangzhou Women′s Hospital,Hangzhou 310006,Zhejiang,China)

机构地区：[1]浙江省杭州市妇产科医院超声科,杭州310000 [2]浙江省杭州市妇产科医院产科,杭州310000 [3]浙江省杭州市妇产科医院检验科,杭州310000

出　　处：《中国性科学》2020年第2期88-92,共5页Chinese Journal of Human Sexuality

基　　金：浙江省杭州市卫生科技计划项目(2017A53)

摘　　要：目的探讨亚临床甲减孕妇胎儿的超声特征,并分析其超声特征与胎儿发育的相关性。方法选取浙江省杭州市妇产科医院行产前检查的24周~40周亚临床甲减孕妇63例(亚甲减组),并选取同期行产检的孕妇63例作为对照组。分析正常孕妇腹中胎儿甲状腺体积及甲状腺分数与孕周的关系,比较两组不同孕期胎儿生理物理评分(IFBS)和脐动脉收缩末期峰值与舒张末期峰值(S/D值)及不同孕周胎儿甲状腺体积和甲状腺分数,并统计分析亚甲减组的可疑病例情况。结果正常孕妇腹中胎儿甲状腺体积及甲状腺分数与孕周均成正相关(r=0.906,0.628,均P<0.05)。亚甲减组胎儿孕中、晚期S/D值及IFBS评分比较差异均无统计学意义;而对照组患者孕晚期S/D值及IFBS评分显著高于孕中期,差异均具有统计学意义(均P<0.05);亚甲减组中、晚期S/D值及IFBS评分均显著低于对照组,差异均具有统计学意义(均P<0.05);两组胎儿各孕期甲状腺体积及分数比较差异无统计学意义(均P>0.05)。结论亚临床甲减孕妇的胎儿超声特征存在显著异常,孕晚期胎儿甲状腺体积及分数与孕周相关,超声可作为甲状腺发育水平的筛查工具。Objective To explore the fetal ultrasound characteristics of pregnant women with subclinical hypothyroidism(SCH),and to analyze the correlation between ultrasound characteristics and fetal development.Methods A total of 63 pregnant women aged 24~40 weeks who underwent prenatal examination of subclinical hypothyroidism from January 2017 to May 2018 in our hospital were selected as SCH group(n=63).Another 63 pregnant women in the same period were selected as the control group(n=63).The relationships between fetal thyroid volume and thyroid fraction and gestational week in healthy pregnant women were analyzed,and the improved fetal biophysical score(IFBS)and S/D values and gestational thyroid volume and thyroid fraction of different gestational weeks were compared between the two groups.Suspicious cases in the SCH group were counted.Results There was a positive correlation between fetal thyroid volume and thyroid fraction and gestational age in healthy pregnant women(r=0.906,0.628,P<0.05).The S/D value and IFBS of the fetuses in the SCH group were significantly lower than those in the control group,with statistically significant differences(all P<0.05).There was no statistically significant difference in thyroid volume and score between the two groups(P>0.05).Conclusions There are significant abnormalities in fetal ultrasound characteristics in pregnant women with SCH.The fetal thyroid volume and score in the third trimester are related to gestational age and can be used as a screening tool for thyroid development.

关 键 词：超声检查 孕妇 亚临床甲减 生物物理评分 胎儿 甲状腺 

分 类 号：R714[医药卫生—妇产科学]