蜘蛛香抗抑郁作用及机制的研究进展  

Anti-depression Effect and Mechanism of Valerianae Jatamansi Rhizoma et Radix

作　　者：李永彪 陈畅[2] 毛森[3] 郭丛[2] 赵婷婷 吴兰兰[1] 王心仪 刘安 闫智勇[1] LI Yong-biao;CHEN Chang;MAO Sen;GUO Cong;ZHAO Ting-ting;WU Lan-lan;WANG Xin-yi;LIU An;YAN Zhi-yong(School of Life Science and Engineering,Southwest Jiaotong University,Chengdu 610031,China;Institute of Chinese Materia Medica,China Academy of Chinese Medical Sciences,Beijing 100700,China;Dongzhimen Hospital,Beijing University of Chinese Medicine,Beijing 100700,China)

机构地区：[1]西南交通大学生命科学与工程学院,成都610031 [2]中国中医科学院中药研究所,北京100700 [3]北京中医药大学东直门医院,北京100700

出　　处：《中国实验方剂学杂志》2020年第2期235-240,共6页Chinese Journal of Experimental Traditional Medical Formulae

基　　金：四川省科学技术厅软科学研究项目(2018ZR0368);四川省科学技术厅重点研发计划项目(2018SZ0078)

摘　　要：以抑郁症为代表的精神类疾病已逐渐成为当前社会快节奏、高压力等人群的主要健康问题之一,严重者可出现自杀等行为,给家庭及整个社会带来巨大的危害甚至是灾难。尽管现代医学在抗抑郁的药物治疗领域取得了长足进步,但仍存在一些不尽人意之处。与此同时,疗效确切、不良反应少、药效温和的传统中药日益受到广泛关注。我国传统中药蜘蛛香用于缓解睡眠障碍有广泛的应用历史,其地下部位提取物在欧洲早已作为温和的镇静剂使用。现代研究表明,蜘蛛香黄酮、挥发油及环烯醚萜等有效部位或提取物在动物及人群试验上均展现了良好的抗抑郁活性,其机制可能与调节脑内神经递质、改善下丘脑-垂体-肾上腺(HPA)轴功能、抗自由基、抗炎、神经保护等有关。在国外,以蜘蛛香作为主要原料治疗抑郁型失眠的保健产品Tagara已上市销售。然而,目前国内对蜘蛛香抗抑郁系统和深入的研究报道还比较缺乏。因此,有必要对蜘蛛香的抗抑郁作用及相关机制进行系统的梳理和总结,以期为蜘蛛香药用资源的进一步开发提供参考。Psychiatric diseases represented by depression have gradually become one of the major health problems of people in the fast-paced,high-pressure society.Severe cases can cause suicides,huge harm or disaster to families and the society.Although modern medicine has made great progress in the field of anti-depressant drug therapy,depression still cannot be cured.At the same time,traditional Chinese medicines(TCM) with a definite curative effect,few adverse reactions,and mild efficacy have received increasing attention.TCM valerianae Jatanmansi Rhizoma et Radix has been widely used to alleviate sleep disorder,and its root extract is popularly known as valerian and used as a mild sedative for a long time in European.Tagara takes Valerianae Jatamansi Rhizoma et Radix as the key ingredient for treatment of depression-type insomnia,and is available abroad.It is reported that iridoid,sesquiterpenes,flavonoids or extract from Valerianae Jatamansi Rhizoma et Radix has a superior anti-depression activity in both animal and clinical trials,and the mechanism is mainly related to the regulation of neurotransmitters in the brain,the improvement of the function of the hypothalamic-pituitary-adrenal(HPA) axis,the resistance of free radicals and inflammation,and the neuroprotective effect.However,there is still lack of report on the anti-depression system and in-depth research of Valerianae Jatamansi Rhizoma et Radix.Therefore,it is urgently necessary to systematically collect and summarize the anti-depressant activity and explain the relevant mechanisms,so as to provide reference for the further development of Valerianae Jatamansi Rhizoma et Radix medicinal resources.

关 键 词：抑郁 蜘蛛香 机制 

分 类 号：R2-0[医药卫生—中医学] R22