基因修饰的脂肪间充质干细胞的研究进展  

Research progress in genetically modified adipose tissue-derived stem cells

作　　者：张晶莹 孙晓林 耿立霞[1] ZHANG Jing-ying;SUN Xiao-lin;GENG Li-xia(Department of Intensive Medicine,Institute of Rheumatology,Department of Rheumatology,the First Affiliated Hospital of Baotou Medical College,Baotou 014010,China;Key Autoimmunity Laboratory of Inner Mongolia,Institute of Rheumatology,Department of Rheumatology,the First Affiliated Hospital of Baotou Medical College,Baotou 014010,China)

机构地区：[1]内蒙古科技大学包头医学院第一附属医院重症医学科,014010 [2]内蒙古科技大学包头医学院第一附属医院中心实验室,014010

出　　处：《天津医药》2019年第12期1273-1276,共4页Tianjin Medical Journal

基　　金：国家自然科学基金资助项目（81860294）;内蒙古自治区科技计划项目（201802089）;内蒙古自然科学基金(2016MS08109)

摘　　要：脂肪间充质干细胞(ADSCs)是来源于脂肪组织的具有多向分化潜能的细胞群,是细胞疗法的理想来源。基因修饰的脂肪间充质干细胞不仅具有ADSCs的全部特性,而且能够高效表达某些外源基因,加强其在疾病治疗中的疗效,为常规的临床治疗方法难以治愈的疾病带来了新的转机。本文就近年来的相关进展进行综述,以期为基因修饰的ADSCs在临床研究的应用上提供借鉴。Adipose mesenchymal stem cells(ADSCs) are multidirectional differentiation potential cells from adipose tissue and are ideal sources of cell therapy. Genetically modified adipose mesenchymal stem cells not only have all the characteristics of ADSCs, but also can express some foreign genes efficiently and enhance their curative effect in the treatment of diseases. The curative effect has brought a new opportunity for diseases that are difficult to be cured by conventional clinical treatment methods. In this paper, the related progress in recent years is reviewed in order to provide reference for the application of gene modified ADSCs in clinical research.

关 键 词：脂肪间充质干细胞 基因修饰 多向分化 综述 

分 类 号：R593.2[医药卫生—内科学]