器官移植排斥反应风险生物标志物研究进展  

Research progress on biomarkers of rejection risk in organ transplantation

作　　者：石炳毅 陈文 刘志佳 Shi Bingyi;Chen Wen;Liu Zhijia(Organ Transplantation Institute of the 8th Medical Center of Chinese PLA General Hospital,Beijing 100091,China)

机构地区：[1]中国人民解放军总医院第八医学中心全军器官移植研究所,北京100091

出　　处：《器官移植》2020年第2期194-198,共5页Organ Transplantation

基　　金：国家自然科学基金(81570680,81571555)。

摘　　要：排斥反应是引起移植失败的最主要原因,目前临床采用的指标特异度和灵敏度均较差,不能精准地提示排斥反应的确切病因,寻找新的排斥反应监测标志物具有十分重要的临床意义。本文从移植病理学、免疫细胞与调节性免疫细胞、非人类白细胞抗原抗体、外泌体、游离DNA、组合基因预测等方面,总结了近年来器官移植排斥反应风险生物标志物研究的最新进展,为器官移植排斥反应预警和治疗提供参考。Rejection is the main cause of transplantation failure.Currently,the specificity and sensitivity of clinical parameters are relatively poor,which cannot accurately prompt the exact cause of rejection.It is of great clinical significance to explore novel biomarkers for monitoring the rejection.In this article,the latest research progress on the biomarkers of rejection risk in organ transplantation were summarized from the perspectives of transplantation pathology,immune cells and regulatory immune cells,non-human leukocyte antigen antibodies,exosomes,cell-free DNA and combination gene prediction,aiming to provide reference for early warning and treatment of rejection in organ transplantation.

关 键 词：器官移植 移植免疫 排斥反应 移植病理学 免疫细胞 非人类白细胞抗原抗体 外泌体 游离DNA(cfDNA) 组合基因预测 

分 类 号：R617[医药卫生—外科学] R392.4[医药卫生—临床医学]