2019 ATC器官移植国际前沿热点及新进展概述  

Overview of international forefront hotspots and new progress on organ transplantation in 2019 ATC

作　　者：王祥慧[1] Wang Xianghui(Kidney Transplant Center,Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine,Shanghai 200025,China)

机构地区：[1]上海交通大学医学院附属瑞金医院肾脏移植中心,200025

出　　处：《器官移植》2020年第2期222-233,共12页Organ Transplantation

基　　金：上海市科委基金项目(10DZ2212000)。

摘　　要：本文概述了2019年美国移植年会(ATC)器官移植临床及应用基础与转化医学研究前沿热点内容,涉及移植科医师普遍关切的移植临床重点及难点,包括供体特异性抗体(DSA)及抗体介导的排斥反应(AMR)的免疫学机制、风险因素、预后评估及重要生物学标志,高致敏患者的去致敏策略及AMR防治进展,临床免疫耐受的现状及发展方向,移植相关感染的热点及防治进展,对供肾机械灌注方法的简要评价等。In this paper,forefront hotspots in clinical and applied basis of organ transplantation as well as translational medicine during 2019 American Transplant Congress(ATC)were summarized.It involved transplantation clinical priorities and difficulties which were concerned by transplant surgeons.These hot topics included the immunological mechanisms,risk factors,prognosis evaluation and important biological markers of donor specific antibody(DSA)and antibody-mediated rejection(AMR),desensitization strategy in highly sensitized patients and progress of AMR prevention and treatment,current status and development direction of clinical immune tolerance,hotspots and prevention progress on transplantation-related infection,and brief evaluation of various donor organ mechanical perfusion methods,etc.

关 键 词：美国移植年会(ATC) 供体特异性抗体(DSA) 抗体介导的排斥反应(AMR) 免疫耐受 移植免疫 移植感染 机械灌注 肾移植 

分 类 号：R617[医药卫生—外科学] R392.4[医药卫生—临床医学]