15-PGDH表达水平与肝癌肝移植临床预后关系研究  

Relationship between expression level of 15-PGDH and clinical prognosis of liver transplantation for hepatocellular carcinoma

作　　者：李海波 汪国营[1] 曾凯宁[1] 张剑文[1] 唐晖[1] 刘炜[1] 杨扬[1] Li Haibo;Wang Guoying;Zeng Kaining;Zhang Jianwen;Tang Hui;Liu Wei;Yang Yang Department of Hepatic Surgery;Liver(Transplantation Center,the Third Affiliated Hospital of Sun Yat-sen University,Organ Transplantation Institute of Sun Yat-sen University,Organ Transplantation Research Center of Guangdong Province,Guangdong Key Laboratory of Liver Disease Research,Guangdong Province Engineering Laboratory for Transplantation Medicine,Guangzhou 510630,China)

机构地区：[1]中山大学附属第三医院肝脏外科暨肝移植中心,中山大学器官移植研究所,广东省器官移植研究中心,广东省肝脏疾病研究重点实验室,广东省移植医学工程实验室,广州510630

出　　处：《器官移植》2020年第2期247-252,281,共7页Organ Transplantation

基　　金：国家“十三五”重大科技专项(2017ZX10203205-006-001);国家重点研发计划项目(2017YFA0104304);国家自然科学基金(81770648,81972286);广东省自然科学基金(2015A030312013,2018A030313259);广东省科技计划项目(2017B020209004,20169013,2017B030314027);广州市科技项目(2014Y2-00200,201604020001)。

摘　　要：目的探讨15-羟基前列腺素脱氢酶(15-PGDH)表达水平与肝细胞癌(肝癌)肝移植临床预后的关系。方法回顾性分析行肝癌肝移植术的94例受者临床资料。用免疫组织化学法检测所有受者病理组织切片中15-PGDH表达情况;分析15-PGDH蛋白表达水平与肝癌患者各项临床参数的关系;计算肝癌肝移植受者术后5年的无瘤生存率和总生存率;分析可能影响肝癌肝移植受者预后的独立危险因素。结果15-PGDH的表达水平与受者的年龄、Child-Pugh分级和术前甲胎蛋白(AFP)水平相关(均为P<0.05)。15-PGDH低表达组受者的无瘤生存率和总生存率均显著低于15-PGDH高表达组受者(均为P<0.05)。15-PGDH表达水平、肿瘤分化程度、美国癌症联合会(AJCC)分期是影响肝癌肝移植受者预后的独立危险因素(均为P<0.05)。结论15-PGDH表达水平是影响肝癌肝移植受者预后的独立危险因素。Objective To investigate the relationship between the expression level of 15-hydroxyprostaglandin dehydrogenase(15-PGDH)and clinical prognosis of liver transplantation for hepatocellular carcinoma.Methods The clinical data of 94 recipients undergoing liver transplantation for hepatocellular carcinoma were retrospectively analyzed.The expression of 15-PGDH in the pathological tissues of all recipients was detected by immunohistochemical staining.The relationship between the expression level of 15-PGDH protein and clinical parameters of hepatocellular carcinoma patients was analyzed.The 5-year tumor-free survival and overall survival rates of liver transplant recipients were calculated.The possible independent risk factors of the clinical prognosis of liver transplant recipients were analyzed.Results The expression level of 15-PGDH was significantly correlated with age,Child-Pugh grade and preoperative level of alpha-fetoprotein(AFP)of the recipients(all P<0.05).The tumor-free survival and overall survival rates of the recipients with low expression of 15-PGDH were significantly lower than those in their counterparts with high expression of 15-PGDH(both P<0.05).The expression level of 15-PGDH,degree of tumor differentiation and American Joint Committee on Cancer(AJCC)staging were the independent risk factors of clinical prognosis of liver transplantation for hepatocellular carcinoma(all P<0.05).Conclusions The expression level of 15-PGDH is an independent risk factor of clinical prognosis of liver transplantation for hepatocellular carcinoma.

关 键 词：肝细胞癌 肝移植 15-羟基前列腺素脱氢酶(15-PGDH) 临床预后 危险因素 无瘤生存率 

分 类 号：R617[医药卫生—外科学] R735.7[医药卫生—临床医学]