急性胰腺炎患者NLR、SAA及PCT与病情严重程度的相关性研究  

Correlation between NLR,SAA and PCT and Severity of Patients with Acute Pancreatitis

作　　者：叶林 武伦 王伟[1] 姚黎超 汤志刚[1] Ye Lin;Wu Lun;Wang Wei(Department of General Surgery,Renmin Hospital of Wuhan University,Hubei 430060,China)

机构地区：[1]武汉大学人民医院普外科,430060

出　　处：《医学研究杂志》2020年第2期25-28,共4页Journal of Medical Research

基　　金：国家自然科学基金资助项目(81272740)。

摘　　要：目的探讨急性胰腺炎(AP)患者的病因和中性粒-淋巴细胞比率(NLR)、血清淀粉样蛋白A(SAA)及降钙素原(PCT)与AP患者病情严重程度的相关性。方法选取收治的AP患者217例,总结其发病原因,并按照Ranson及APACHEⅡ评分分别分为轻症AP组和重症AP组,检测入院24h内血清NLR、SAA及PCT水平。结果AP病因中胆源性AP占43.3%,脂源性AP占25.6%,酒精性AP占12.5%,特发性AP占15.6%;按照Ranson评分、APACHEⅡ评分分组,重症AP组患者NLR、SAA及PCT水平高于轻症AP组(P<0.05);Spearman相关分析,三者皆与患者病情严重程度的评分系统有相关性(APACHEⅡ:r=0.60、r=0.65、r=0.78;Ranson评分:r=0.64、r=0.65、r=0.61,P<0.05)。结论AP患者血清NLR、SAA及PCT水平与病情严重程度密切相关,可应用于临床。Objective To investigate the etiology of acute pancreatitis(AP)and the correlation between neutrophil-lymphocyte ratio(NLR),serum amyloid A(SAA)and procalcitonin(PCT)and the severity of AP.Methods We selected 217 cases of patients with AP,summarized its causes.According to the Ranson and APACHEⅡscores,they were divided into mild AP group and severe AP group.We tested serum NLR,SAA and PCT levels on admission.Results Biliary AP accounted for 43.3%,lipid AP for 25.6%,alcoholic AP for 12.5%,and idiopathic AP for 15.6%.According to the Ranson score and APACHEⅡscore,severe AP patients NLR,SAA and PCT levels were both higher than those in mild AP group(P<0.05).Spearman correlation analysis shoved that they had correlation with Ranson and APACHEⅡscore(APACHEⅡ:r=0.60,r=0.65,r=0.78;Ranson:r=0.64,r=0.65,r=0.61,P<0.05).Conclusion Serum NLR,SAA and PCT levels in AP patients were closely related to the severity of the disease and can be used in clinical practice.

关 键 词：急性胰腺炎 NLR SAA PCT Ranson APACHEⅡ 

分 类 号：R4[医药卫生—临床医学]