老年阻塞性睡眠呼吸暂停低通气综合征患者冠心病发病风险的调查  

Risk of CHD in elderly patients with obstructive sleep apnea-hypopnea syndrome

作　　者：林文婷[1] 曾敏[1] 陈积雄[1] 何扬利[1] 蒙绪卿[1] 符秀虹[1] Lin Wenting;Zeng Min;Chen Jixiong;He Yangli;Meng Xuqing;Fu Xiuhong(Hainan Hospital Healthcare Center,Haikou 570311,Hainan Province,China)

机构地区：[1]海南省人民医院医疗保健中心

出　　处：《中华老年心脑血管病杂志》2020年第2期153-155,共3页Chinese Journal of Geriatric Heart,Brain and Vessel Diseases

基　　金：国家自然科学基金(81760054,81260043);海南省重点科技计划项目(ZDXM2014065);海南省自然科学基金(2016CXTD011)

摘　　要：目的对老年阻塞性睡眠呼吸暂停低通气综合征(OSAHS)患者冠心病的发病风险进行调查。方法选择2015年5月~2018年5月海南省人民医院经整夜多导睡眠监测诊断为OSAHS患者60例,根据患者病情严重程度分为轻度组19例,中度组18例,重度组23例。按2︰1原则选择同期我院健康体检中心进行体检的非OSAHS患者30例(对照组)。采集各组患者基本信息,通过多导睡眠监测仪监测呼吸暂停低通气指数(AHI),根据AHI评估患者病情,进一步采用Framingham危险评分及欧洲心脏外科手术风险评估系统(EuroSCORE)对研究对象进行评估。结果与对照组比较,中度组和重度组Framingham危险评分和EuroSCORE明显升高[(7.94±3.49)分、(10.30±3.01)分vs(2.82±1.39)分,(2.25±0.86)分、(3.25±0.85)分vs(1.31±0.48)分,P<0.05)]。相关性分析显示,OSAHS患者AHI分别与Framingham危险评分及EuroSCORE呈正相关(r=0.709,P=0.028;r=0.726,P=0.019)。结论老年OSAHS患者随着病情的加重,冠心病相关事件发生风险明显升高。Objective To study the risk of coronary heart disease(CHD)in elderly patients with obstructive sleep apnea-hypopnea syndrome(OSAHS).Methods Sixty OSAHS patients admitted to our hospital from May 2015 to May 2018 were divided into mild OSAHS group(n=19),moderate OSAHS group(n=18)and severe OSAHS group(n=23)with 30 OSAHS-free patients undergoing physical examination in our hospital served as a control group.Their baseline clinical data and apnea-hypopnea index(AHI)were recorded.The condition of OSAHS patients was assessed according to their AHI,Framingham hazard score and European risk assessment system for cardiac surgery(EuroSCORE)score respectively.Results The Framingham hazard score and EuroSCORE score were significantly higher in moderate and severe OSAHS groups than in control group(7.94±3.49 and 10.30±3.01 vs 2.82±1.39,2.25±0.86 and 3.25±0.85 vs 1.31±0.48,P<0.05).Spearman correlation analysis showed that the AHI was positively related with the Framingham hazard score and EuroSCORE score in OSAHS patients(r=0.709,P=0.028;r=0.726,P=0.019).Conclusion The risk of CHD-related events increases significantly in elderly OSAHS patients with the aggravation of their condition.

关 键 词：睡眠呼吸暂停 阻塞性 冠心病 高血压 心力衰竭 

分 类 号：R766[医药卫生—耳鼻咽喉科] R541.4[医药卫生—临床医学]