阿司匹林联合芬吗通对重度宫腔粘连术后预后的影响  

Effect of Aspirin combined with Fentanyl on the prognosis of patients with severe uterine cavity adhesionsurgery

作　　者：李莉 王敏 LI Li;WANG Min(Department of Family Planning,the Beijing Tongzhou District Maternal and Child Health Care,Beijing 101101,China;Department of Gynaecology,the Beijing Tongzhou District Maternal and Child Health Care,Beijing 101101,China)

机构地区：[1]北京市通州区妇幼保健院计划生育科,北京101101 [2]北京市通州区妇幼保健院妇科,北京101101

出　　处：《河北医科大学学报》2020年第2期158-162,共5页Journal of Hebei Medical University

摘　　要：目的观察阿司匹林与芬吗通联合使用对于重度宫腔粘连术后患者月经改善率、子宫动脉血流及子宫内膜修复的治疗效果。方法108例重度宫腔粘连的育龄妇女随机分为观察组和对照组各54例,2组均行宫腔粘连分离手术,对照组术后给予芬吗通连续口服进行治疗,观察组在此基础上给予阿司匹林连续服用1个月。观察2组临床疗效、总有效率、妊娠情况,比较2组子宫内膜厚度和月经量以及子宫动脉血流参数。结果观察组临床疗效和宫腔形态恢复总有效率均优于对照组(P<0.05);观察组试孕19例,成功13例(68.43%),对照组试孕15例,成功5例(33.34%),观察组妊娠成功率高于对照组(P<0.05);治疗后2组子宫内膜厚度和经血量均较治疗前明显改善(P<0.05),治疗组子宫内膜厚度和经血量均较对照组明显改善(P<0.05);2组子宫动脉血流参数动脉阻力指数(resistance index,RI)、搏动指数(pulse index,PI)均较治疗前减低,血管化指数(vascularization index,VI)、血管化血流指数(vascularization flow index,VFI)、血流指数(flow index,FI)较治疗前升高(P<0.05),治疗后观察组RI、PI均低于对照组,VI、VFI、FI均高于对照组(P<0.05);2组不良反应差异无统计学意义(P>0.05)。结论阿司匹林联合芬吗通治疗重度宫腔粘连术后患者能够促进其子宫内膜修复,改善其月经及动脉血流情况,安全性好。Objective To study the effect of Aspirin combined with Femoston on the improvement rate of menstruation,uterine artery blood flow and endometrial repair in patients after severe intrauterine adhesions surgery.Methods One hundred and eight women of childbearing age with severe intrauterine adhesions were randomly divided into observation group and control group with 54 cases in each group.All patients in the two groups underwent uterine adhesions separation surgery.The patients in control group were treated with Fenmotong orally after operation.On this basis,the observation group was given Aspirin for a long period of one month.The clinical efficacy and total effective rate of the two groups were observed.Pregnancy status,endometrial thickness,menstrual volume and uterine artery blood flow parameters of the two groups were compared.Results The total effective rate of clinical efficacy and uterine cavity shape recovery in the observation group was significantly higher than that in control group(P<0.05).Nineteen cases were pregnant in observation group,13 cases were successful(68.43%)and 15 cases in the control group,5 cases were successful(33.34%).The pregnancy success rate in observation group was higher than that in control group(P<0.05).After treatment,the endometrial thickness and menstrual blood volume of the two groups were significantly improved compared with those before treatment(P<0.05).The improvement of endometrial thickness and menstrual blood volume in the treatment group was higher than that before treatment and in control group(P<0.05).Resistance index(RI)and pulse index(PI)of uterine artery blood flow parameters in two groups were lower than before treatment,vascularization index(VI),vascularization flow index(VFI)and flow index(FI)were higher than before treatment,RI and PI in observation group were lower than that in control group after treatment,VI,VFI and FI in observation group were higher than that in control group after treatment(P<0.05).There was no significant difference in adverse reactio

关 键 词：ASHERMAN综合征 阿司匹林 芬吗通 预后 

分 类 号：R711.73[医药卫生—妇产科学]