造血干细胞移植治疗再生障碍性贫血的现状  

Current status of hematopoietic stem cell transplantation in the treatment of aplastic anemia

作　　者：魏元凤 黄东平[1] Wei Yuanfeng;Huang Dongping(Department of Hematopathology,Yijishan Hospital of Wannan Medical College,Wuhu 241000,Anhui Province,China)

机构地区：[1]皖南医学院弋矶山医院血液内科

出　　处：《中国组织工程研究》2020年第19期3093-3100,共8页Chinese Journal of Tissue Engineering Research

基　　金：安徽省重点研究与开发计划项目(201904a07020036)，项目负责人：黄东平~~

摘　　要：背景:异基因造血干细胞移植治疗再生障碍性贫血的研究近年来取得很大的进步,但是移植后移植物抗宿主病、移植失败等仍是患者非复发死亡的主要原因,严重影响患者生存。目的:总结异基因造血干细胞移植治疗再生障碍性贫血的现状及进展。方法:中文检索词为“再生障碍性贫血,同胞全合异基因造血干细胞移植,无关供者造血干细胞移植,单倍体造血干细胞移植,脐血造血干细胞移植”,英文检索词为“aplastic anemia,matched sibling donor hematopoietic stem cell transplantation,unrelated donor hematopoietic stem cell transplantation,haploidentical hematopoietic stem cell transplantation,cord blood transplantation”,由第一作者检索1990年1月至2019年9月在PubMed、中国知网、万方、维普等数据库中发表的与造血干细胞移植治疗再生障碍性贫血相关的文献,最终选择55篇文献进行分析。结果与结论:同胞全合异基因造血干细胞移植仍是目前首选的移植方式;对于无同胞全合供者的重型再生障碍性贫血患儿,一线治疗可以选择无关供者相合异基因造血干细胞移植;缺乏全合供者时,单倍体移植和脐血移植亦为不错的选择。BACKGROUND:A great progress has been achieved in the allogeneic hematopoietic stem cell transplantation for aplastic anemia.However,graft-versus-host disease and graft failure after transplantation are still the main causes of non-relapse death,which seriously affect the survival of patients.OBJECTIVE:To summarize the current status and progress of allogeneic hematopoietic cell transplantation in the treatment of aplastic anemia.METHODS:The first author retrieved PubMed,CNKI,WanFang and VIP databases for the articles concerning allogeneic hematopoietic stem cell transplantation for aplastic anemia published from January 1990 to September 2019.The keywords were“aplastic anemia,matched sibling donor hematopoietic stem cell transplantation,unrelated donor hematopoietic stem cell transplantation,haploidentical hematopoietic stem cell transplantation,cord blood transplantation”in Chinese and English,respectively.Finally 55 eligible articles were included for result analysis.RESULTS AND CONCLUSION:HLA-matched sibling donor allogeneic hematopoietic stem cell transplantation is the first choice.Unrelated donor hematopoietic stem cell transplantation may be an effective and feasible first-line therapy in pediatric severe aplastic anemia patients with no matched sibling donors.Haploidentical hematopoietic stem cell transplantation and cord blood transplantation can also be important transplantation methods for severe aplastic anemia when lack of HLA-matched donors.

关 键 词：再生障碍性贫血 造血干细胞移植 同胞全合供者 无关供者 单倍体移植 脐血移植 

分 类 号：R457[医药卫生—治疗学] R394.2[医药卫生—临床医学]