血红素氧化酶1与慢性阻塞性肺疾病的研究进展  

Research progress of heme oxygenase-1 and chronic obstructive pulmonary disease

作　　者：李炜霞 张家强[1] 赵芝焕[1] Li Weixia;Zhang Jiaqiang;Zhao Zhihuan(The Second Department of Respiratory and Critical Care Medicine,the First Affiliated Hospital of Kunming Medical University,Kunming 650032,China)

机构地区：[1]昆明医科大学第一附属医院呼吸与危重症医学二科,650032

出　　处：《国际呼吸杂志》2020年第2期118-121,共4页International Journal of Respiration

摘　　要：慢性阻塞性肺疾病(COPD)是以持续气流受限为特征的可以预防和治疗的呼吸道疾病。其发生机制尚未完全明确,近年来许多研究表明氧化应激、基因多态性在其发生、发展过程中起到非常重要的作用。血红素加氧酶1(HO-1)作为体内重要的氧化还原酶,与COPD关系密切。本文将从HO-1与COPD的发生、发展、治疗及预后等方面的关系进行综述,以期为COPD的诊断、治疗及管理提供新思路。Chronic obstructive pulmonary disease(COPD)is a preventable and treatable respiratory disease characterized by persistent airflow limitation.Its mechanism has not yet been fully clarified.In recent years,many studies have shown that oxidative stress and gene polymorphism play a very important role in its development.Heme oxygenase-1(HO-1)is an important oxygen reductase in the body and is closely related to COPD.This article reviews the relationship between the occurrence,development,treatment and prognosis of HO-1 and COPD,in order to provide new ideas for the diagnosis,treatment and management of COPD.

关 键 词：肺疾病 慢性阻塞性 基因 重复 血红素加氧酶1 

分 类 号：R563[医药卫生—呼吸系统]