慢性阻塞性肺疾病骨骼肌功能障碍研究及相关肺康复进展  

Research progress of skeletal muscle dysfunction and related pulmonary rehabilitation in chronic obstructive pulmonary disease

作　　者：赵亭亭 李冬艳[2] Zhao Tingting;Li Dongyan(Shanxi Medical University,Taiyuan 030001,China;Department of Respiratory and Critical Care Medicine,the First Hospital of Shanxi Medical University,Taiyuan 030001,China)

机构地区：[1]山西医科大学,太原030001 [2]山西医科大学第一医院呼吸与危重症医学科,太原030001

出　　处：《国际呼吸杂志》2020年第2期127-131,共5页International Journal of Respiration

摘　　要：骨骼肌功能障碍作为慢性阻塞性肺疾病常见的肺外效应之一,严重影响患者的运动耐力、生活质量和预后。其机制可能是在多因素病因的作用下,骨骼肌发生了一些生物学事件,如结构异常、氧化应激、肌肉蛋白代谢紊乱(分解增加/合成减少)、自噬、表观遗传调节、细胞凋亡、内质网应激等。目前运动训练、神经肌肉电刺激、营养支持等肺康复干预措施被证实可用于骨骼肌功能障碍的防治。As one of the common extrapulmonary effects of chronic obstructive pulmonary disease,skeletal muscle dysfunction seriously affects patients'exercise endurance,quality of life and prognosis.The mechanism may be that under the action of multifactorial etiology,some biological events occur in skeletal muscle,such as structural abnormality,oxidative stress,muscle protein metabolism disorder(increased proteolysis/decreased protein synthesis),autophagy,epigenetic regulation,cell apoptosis,endoplasmic reticulum stress,etc.At present,exercise training,neuromuscular electrical stimulation,nutritional support and other pulmonary rehabilitation interventions have been proved to be suitable for the prevention and treatment of skeletal muscle dysfunction.

关 键 词：肺疾病 慢性阻塞性 骨骼肌功能障碍 生物学机制 肺康复 

分 类 号：R563[医药卫生—呼吸系统]