维生素A、E辅助药物治疗儿童反复呼吸道感染的疗效及免疫状态分析  

Analysis on clinical effect of vitamin A,vitamin E combined with drug therapy in treatment of children with recurrent respiratory tract infection and immune status

作　　者：钱铃 章雷花 杨华飞[2] QIAN Ling;ZHANG Lei-Hua;YANG Hua-Fei(Department of Pediatrics,People's Hospital of Liandu District,Lishui,Zhejiang 323006,China)

机构地区：[1]丽水市莲都区人民医院儿科,浙江丽水323006 [2]丽水市人民医院儿科,浙江丽水323000

出　　处：《中国妇幼保健》2020年第1期50-53,共4页Maternal and Child Health Care of China

基　　金：国家卫生计生委医药卫生科技发展研究项目(W2015EAE039)

摘　　要：目的分析维生素A、E辅助药物治疗儿童反复呼吸道感染的疗效及免疫状态。方法选择2016年3月-2018年1月就诊的100例儿童反复呼吸道感染患儿,根据随机双盲法进行分组。对照组50例,单用匹多莫德治疗;研究组50例,在匹多莫德治疗基础上加用维生素A、E辅助治疗,均治疗3周。比较两组临床疗效、治疗相关指标、不良反应,并观察治疗前、治疗3周后T淋巴细胞亚群、免疫球蛋白及维生素A、E水平变化。结果研究组治疗总有效率比对照组高(P<0. 05)。研究组治愈时间、感染持续时间比对照组短,感染次数比对照组低(均P<0. 05)。治疗3周后,研究组CD3^+T淋巴细胞亚群水平比对照组高,CD4^+T淋巴细胞亚群、CD8^+T淋巴细胞亚群水平比对照组低(均P <0. 05),IgA、IgG、IgM水平比对照组高(均P <0. 05),维生素A、E水平比对照组高(均P<0. 05)。两组治疗前后T淋巴细胞亚群、免疫球蛋白水平及维生素A、E水平比较差异均有统计学意义(均P<0. 05)。两组不良反应发生率比较差异无统计学意义(P>0. 05)。结论维生素A、E辅助药物治疗儿童反复呼吸道感染疗效确切,可降低患儿疾病复发次数,缩短病程,调节细胞及体液免疫功能,加强机体抗病能力,且安全性较高,利于获得良好预后。Objective To analyze the clinical effect of vitamin A,vitamin E combined with drug therapy in treatment of children with recurrent respiratory tract infection( RRTI) and immune status. Methods From March 2016 to January 2018,100 children with RRTI were selected and divided into two groups according to random double-blind method. Fifty children in control group were treated by pidotimod.Fifty children in study group were treated by vitamin A and vitamin E based on pidotimod. The children in the two groups were treated for three weeks. The clinical effects,treatment indexes,and adverse reactions in the two groups were compared. The changes of T lymphocyte subsets,immunoglobulins,vitamin A,vitamin E levels before treatment and at 3 weeks after treatment were observed. Results The total effective rate in study group was statistically significantly higher than that in control group( P<0. 05). The cure time and duration of infection in study group were statistically significantly shorter than those in control group,and the times of infection in study group was statistically significantly lower than that in control group( P<0. 05). After treatment for 3 weeks,the level of CD3+T lymphocyte subgroup in study group was statistically significantly higher than that in control group,while the levels of CD4+T lymphocyte subgroup and CD8+T lymphocyte subgroup in study group were statistically significantly lower than those in control group( P<0. 05),the levels of Ig A,Ig G,and Ig M in study group were statistically significantly higher than those in control group( P<0. 05),the levels of vitamin A and vitamin E in study group were statistically significantly higher than those in control group( P<0. 05). In the two groups,there were statistically significant differences in the levels of T lymphocyte subgroups,immunoglobulins,vitamin A,and vitamin E between before and after treatment( P< 0. 05). There was no statistically significant difference in the incidence rate of adverse reactions between the two groups( P> 0. 05). Conclusio

关 键 词：儿童反复呼吸道感染 维生素A 维生素E 匹多莫德 免疫状态 

分 类 号：R725.6[医药卫生—儿科]