抗-G联合抗-D、抗-C抗体导致交叉配血不合临床分析  

Clinical analysis of incompatibility in blood crossmatching induced by anti-G,anti-D and anti-C antibodies

作　　者：杨红梅[1] 郑皆炜[2] 向东[2] 沈伟[2] 许飞[1] 曹锁春[1] YANG Hongmei;ZHENG Jiewei;XIANG Dong;SHEN Wei;XU Fei;CAO Suochun(Changzhou Blood Center,Changzhou,213004,China;Shanghai Blood Center)

机构地区：[1]常州市中心血站,江苏常州213004 [2]上海市血液中心

出　　处：《临床血液学杂志（输血与检验）》2019年第6期918-921,共4页Journal of Clinical Hematology(Blood Transfusion & Laboratory Medicine)

基　　金：常州市卫计委指导性课题(No:WZ201729);江苏省输血协会英科新创科研基金课题(No:JS2018037)

摘　　要：目的:探讨交叉配血中抗-G联合抗-D、抗-C抗体引起配血不合的原因。方法:通过ABO血型鉴定、Rh分型、直接抗人球蛋白试验、不规则抗体筛查、抗体特异性鉴定、吸收放散试验及抗体效价测定对患者配血不合进行分析。结果:对照细胞谱反应格局,患者血清中检出抗-D、抗-C及抗-G抗体。结论:患者血清中不规则抗体是导致交叉配血不合的主要原因。Objective:To investigate the reason of anti-G,anti-D combined with anti-C antibodies inducing incompatibility in blood crossmatching. Method:Through ABO blood typing,direct Coombs test,irregular antibody screening,absorption and elution and antibody titer determination experiments to determine and analyze the incompatibility in blood crossmatching failed for several times. Result:Anti-D,anti-C and anti-G antibodies were detected in the serum of patients according to the pattern of cell spectrum reaction.Conclusion:Irregular antibodies in the serum of patients might be an important cause of crossmatch discord.

关 键 词：交叉配血 抗体筛查 抗-G抗体 不规则抗体 

分 类 号：R457.1[医药卫生—治疗学]