Ultrasound-responsive Homopolymer Nanoparticles  

作　　者：Bo Yang Jian-Zhong Du 

机构地区：[1]Department of Orthopedics,Shanghai Tenth People's Hospital,Tongji University School of Medicine,Shanghai 200072,China [2]Department of Polymeric Materials,School of Materials Science and Engineering,Key Laboratory of Advanced Civil Engineering Materials of Ministry of Education,Tongji University,Shanghai201804,China

出　　处：《Chinese Journal of Polymer Science》2020年第4期349-356,I0006,共9页高分子科学（英文版）

基　　金：supported by the National Natural Science Foundation of China(No.21674081);Fundamental Research Funds for the Central Universities(No.22120180109)。

摘　　要：Nonin vasive ultraso und is a more effective strategy for on-demand drug delivery of polymeric nano particles than many other stimuli.However,the preparation of ultrasound-responsive homopolymer nanoparticles is still very challenging.In this study,we disclose the regulating factors of ultrasound responsiveness of homopolymer nanoparticles and the disaggregation behavior of homopolymer nanoparticle aggregates.Homopolymer nanoparticles such as vesicles and large compound micelles(LCMs)are self-assembled from poly(methoxyethyl methacrylate)(PMEMA)and poly(amic acid)(PAA),respectively.The ultrasound responsiveness of PAA vesicles at metastable state could be regulated by tuning the self-assembly temperature(7^),and was optimized when Ts is around the glass transition temperature(7g)of PAA.However,the PMEMA LCMs did not respond to ultrasound as they are at stable state.On the other hand,poly(2-(2-ethoxyethoxy)ethyl acrylate)(PEEA)could self-assemble into vesicle aggregates or complex micelle aggregates,which were dissociated upon sonication.Overall,the above findings provide us with a fresh in sight for designing ultrasound-responsive polymeric nanoparticles.

关 键 词：Ultrasound responsiveness HOMOPOLYMERS Vesicles Micelles SELF-ASSEMBLY 

分 类 号：TB383.1[一般工业技术—材料科学与工程]