冠状动脉侧支生长机制和潜在的治疗靶点  

Mechanisms and potential therapeutic targets for coronary collateral growth

作　　者：张梦洋 樊吉文 刘亚聪 刘全[1] Zhang Mengyang;Fan Jiwen;Liu Yacong;Liu Quan(Department of Cardiology,the First Hospital Affiliated to Jilin University,Changchun 130021,China)

机构地区：[1]吉林大学第一医院心血管疾病诊疗中心,长春130021

出　　处：《中华老年医学杂志》2020年第1期96-99,共4页Chinese Journal of Geriatrics

基　　金：国家自然科学基金面上项目资助课题(81670343);吉林省科技发展计划项目(20190701066GH)。

摘　　要：诱导冠状动脉侧支循环生长即治疗性血管新生是冠心病有效的治疗方法,但冠状动脉侧支生长是一个复杂的过程,与多种因素相关。虽然在动物实验中取得了较好的结果,但现有的临床试验未能复制这些结果。切实可行的临床治疗方案仍有待于对冠脉侧支生长机制的进一步研究。Induction of coronary collateral circulation,that is,therapeutic angiogenesis,is considered a promising treatment for coronary heart disease.However,coronary collateral growth is a complex process and is related to a variety of factors.Although it has achieved promising outcomes in animal experiments,clinical trials have so far failed to replicate these results.Further studies on the growth mechanisms of coronary collateral circulation are still needed before a feasible clinical treatment strategy becomes available.

关 键 词：冠状动脉循环 侧支循环 

分 类 号：R54[医药卫生—心血管疾病]