吸入性麻醉药恩氟烷的红外光谱研究  

Study on the infrared spectrum of inhalational anesthetics enflurane

作　　者：武玉洁 左凯亚 李永宽 贾永杰 于卉 董妍 杨若冰 于宏伟[2] Wu Yujie;Zuo Kaiya;Li Yongkuan;Jia Yongjie;Yu Hui;Dong Yan;Yang Ruobing;Yu Hongwei(Hebei Yipin Pharmaceutical Corporation Ltd.,Shijiazhuang 052165,China;School of Chemical Enginerring,Shijiazhuang University,Shijiazhuang 050035,China)

机构地区：[1]河北一品制药股份有限公司,河北石家庄052165 [2]石家庄学院化工学院,河北石家庄050035

出　　处：《煤炭与化工》2019年第11期144-151,159,共9页Coal and Chemical Industry

基　　金：河北省麻醉药技术创新中心自研项目(2019);石家庄市麻醉药技术创新中心自研项目(2019)

摘　　要：采用3种红外(IR)光谱方法(包括透射IR光谱/T-IR光谱、衰减全反射IR光谱/ATR-IR光谱和漫反射IR光谱/DR-IR光谱)开展了恩氟烷的分子结构研究。实验发现,恩氟烷的红外吸收模式主要包括恩氟烷CH伸缩振动模式(νCH-恩氟烷)、恩氟烷CF2伸缩振动模式(νCF2-恩氟烷)和恩氟烷CF伸缩振动模式(νCF-恩氟烷)等;恩氟烷T-IR光谱质量要优于相应的ATR-IR光谱和DR-IR光谱。本项研究拓展了IR光谱在重要的吸入性麻醉药(恩氟烷)结构研究的应用研究范围。The molecular structure of enflurane was studied by infrared(IR)spectrum methods(including transmission IR spectrum/T-IR spectrum,attenuated total reflection IR spectrum/ATR-IR spectrum and diffuse reflectance IR spectrum/DR-IR pectrum).It is found that the infrared absorption modes of enflurane mainly include the CH stretch vibration mode(νCH-enflurane),the CF2 stretch vibration mode(νCF2-enflurane)and CF stretch vibration mode(νCF-enflurane),the quality of enflurane T-IR spectrum is better than enflurane ATR-IR spectrum and enflurane DR-IR spectrum.This study expands the scope of application of IR spectroscopy in the study of the structure of important inhaled anesthetics(enflurane).

关 键 词：恩氟烷 红外光谱 结构 

分 类 号：O434.3[机械工程—光学工程]