血清Myo、cTnI、IMA联合检测对AMI诊断及病情评估的价值  

Value of Combined Detection of Serum Myo,cTnI and IMA in the Diagnosis and Condition Evaluation of AMI

作　　者：任洁[1] 郑涛 胡经文[1] 李跳跳 REN Jie;ZHENG Tao;HU Jing-wen(The First Affiliated Hospital of Xi'an Jiaotong University,Xi'an 710061)

机构地区：[1]西安交通大学第一附属医院心血管内科,陕西西安710061

出　　处：《医学临床研究》2019年第12期2343-2345,共3页Journal of Clinical Research

摘　　要：【目的】探讨缺血性修饰蛋白(IMA)、肌钙蛋白I(cTnI)及肌红蛋白(Myo)联合检测对急性心肌梗死(AMI)诊断及病情评估的价值。【方法】选择本院收治的120例AMI患者(观察组)以及同期健康体检的健康志愿者120例(对照组),检测两组研究对象血清Myo、cTnI、IMA水平并比较不同冠脉病变患者血清Myo、cTnI、IMA水平变化,采用受试者工作曲线(ROC)分析三者联合应用鉴别诊断AMI的价值。【结果】观察组患者血清Myo、cTnI、IMA水平均显著高于对照组,差异有统计学意义(P<0.05)。三支病变、双支病变的AMI组患者血清Myo、cTnI、IMA水平均高于单支冠脉病变的患者,三支病变的AMI组患者的血清Myo、cTnI、IMA水平均显著高于双支冠脉病变的患者,差异均有统计学意义(P<0.05)。血清Myo、cTnI、IMA水平联合检测诊断AMI的灵敏度为96.38%、特异度为90.11%、漏诊率为3.62%、误诊率为9.89%、AUC值为0.932。【结论】血清Myo、cTnI、IMA水平联合检测对于及早期诊断判断AMI病情均具有一定的临床价值。【Objective】To explore the value of combined detection of IMA,cTnI and myo in the diagnosis and condition evaluation of acute myocardial infarction(AMI).【Methods】One hundred and twenty patients with AMI(observation group)and 120 healthy volunteers(control group)treated in our hospital were selected.The serum Myo,cTnI,IMA levels of the two groups were measured and the changes of serum Myo,cTnI,IMA levels of patients with different coronary artery lesions were compared.The value of differential diagnosis of AMI was analyzed by ROC analysis of the working curve of the subjects.【Results】The level of serum Myo,cTnI,IMA in the observation group was significantly higher than that in the control group(P<0.05).The level of serum Myo,cTnI,IMA in patients with three-vessel disease and two-vessel disease in the AMI group was higher than that in patients with single-vessel coronary artery disease.The serum levels of myo,cTnI and IMA of the patients with three-vessel deaease in the AMI group were significantly higher than those with two vessel disease(P<0.05).).The diagnosis of AMI by serum Myo,cTnI and IMA showed that the sensitivity was 96.38%,the specificity was 90.11%,the missed diagnosis rate was 3.62%,the misdiagnosis rate was 9.89%,and the AUC value was 0.932.【Conclusion】The combined detection of serum Myo,cTnI and IMA has a certain clinical value for the early diagnosis of AMI.

关 键 词：心肌梗死 急性病 白蛋白类/血液 肌钙蛋白I/血液 

分 类 号：R542.22[医药卫生—心血管疾病]