血浆网膜素-1水平在慢阻肺患者病情评估中的应用价值  

The value of plasma reticulin-1 level in the evaluation of COPD patients

作　　者：唐楠[1] 陶韬[1] 周学刚 况菊 廖秀清[1] 王导新[2] TANG Nan;TAO Tao;ZHOU Xuegang;KUANG Ju;LIAO Xiuqing;WANG Daoxin(Department of Respiratory Medicine,Fuling Central Hospital,Chongqing 408000,China;Department of Respiratory Medicine,The Second Affiliated Hospital of Chongqing Medical University,Chongqing 400010,China)

机构地区：[1]重庆市涪陵中心医院呼吸内科,重庆408000 [2]重庆医科大学附属第二医院呼吸内科,重庆400000

出　　处：《西部医学》2020年第1期56-60,共5页Medical Journal of West China

基　　金：重庆市涪陵区科技计划项目(FLKJ,2018BBB3027)

摘　　要：目的探讨COPD患者血浆网膜素-1(Omentin-1)水平与病情严重程度的相关性。方法选取重庆市涪陵中心医院呼吸内科2017年8月~2018年7月收治的中老年COPD患者124例,按照病程分为急性加重组(64例)与稳定期组(60例),另选取60例健康成人作为对照组;稳定期COPD患者急性加重风险评估分为A、B、C、D四组;急性加重组按照病情严重程度分为无呼吸衰竭(1级)、急性呼吸衰竭-无生命危险(2级)、急性呼吸衰竭-有生命危险(3级)3个级别。分别检测血浆网膜素-1水平。结果急性加重组和稳定期组患者的血浆网膜素-1水平均显著低于对照组(P<0.05);与稳定期组比较,急性加重组的血浆网膜素-1水平更低(P<0.01);稳定期COPD患者急性加重风险评估中B组与C组、C组与D组比较差异有统计学意义(P<0.05),且发现症状越重,其Omentin-1水平越低。在急性加重组,3个病情级别的血浆网膜素-1水平依次降低,且两两比较差异均有统计学意义(P<0.05);急性加重组患者的病情严重程度分级与其血浆网膜素-1水平呈显著负相关(r=-0.525)。结论血浆网膜素-1有望成为一种预测COPD病情严重程度的生物标记物。Objective To investigate the relationship between the level of plasma omentin 1 and the severity of COPD. Methods From August 2017 to July 2018, 124 middle-aged and elderly patients with COPD were selected from respiratory department of Fuling Central Hospital of Chongqing. According to the course of disease, they were divided into acute exacerbation(64 cases) and stable period group(60 cases). Another 60 healthy adults were selected as the control group. The risk assessment of acute exacerbation in stable COPD patients was divided into group A, group B, group C and group D. According to the severity of the disease, acute exacerbation was divided into no respiratory failure(Level 1), acute respiratory failure(Level 2), and acute respiratory failure(Level 3). The levels of plasma reticulin 1 were measured. Results The level of plasma reticulin-1 in the acute exacerbation and stable phase group was significantly lower than that in the control group(P<0.05). Compared with the stable group, the level of plasma reticulin-1 in the acute exacerbation group was lower(P<0.01). There was significant difference between group B and group C, between group C and group D in the risk assessment of acute exacerbation of COPD in stable stage(P<0.05). The more serious the symptoms were, the lower the level of omentin 1 was. In acute exacerbation, the levels of plasma reticulin-1 in three grades decreased in turn, and there was significant difference between the two groups(P<0.05). There was a significant negative correlation between the severity of acute exacerbation and the level of plasma reticulin-1(r=-0.525). Conclusion Plasma reticulin-1 may be a biomarker to predict the severity of COPD.

关 键 词：慢性阻塞性肺疾病 OMENTIN-1 相关性 病情评估 炎症反应 

分 类 号：R563[医药卫生—呼吸系统]