触摸屏防指纹纳米涂层材料应用致有机氟中毒特征分析  

Characteristic analysis of organic fluorosis caused by appliying of touch screen anti-fingerprint nanocoating material

作　　者：马争[1] 彭建梅 朱志良[2] 陈满连[1] 蔡木蔚[1] 左金宝[1] 庄小舟[1] Ma Zheng;Peng Jianmei;Zhu Zhiliang;Chen Manlian;Cai Muwei;Zuo Jinbao;Zhuang Xiaozhou(Dongguan Sixth People's Hospital,Dongguan 523008,China;Shenzhen Baoan Center for Disease Control and Prevention)

机构地区：[1]东莞市第六人民医院,东莞市职业病防治中心,523008 [2]深圳市宝安区疾病预防控制中心,518101

出　　处：《中华劳动卫生职业病杂志》2019年第12期921-925,共5页Chinese Journal of Industrial Hygiene and Occupational Diseases

基　　金：广东省医学科研基金立项项目(B2018157);东莞市社会科技发展(重点)项目(2018507150051626);东莞市市属公立医院院长专项资金重点专科建设项目(东医管[2016]10号)。

摘　　要：目的探讨手机触屏玻璃防指纹涂层材料应用致有机氟中毒的致病条件和临床特征。方法以2019年6月17日至2019年7月6日发生急性有机氟中毒企业共22名工人为调查对象,其中包装一车间6名员工作为有机氟接触组,其他车间16名员工为非接触组,通过工作场所职业卫生调查职业病危害因素检测和职业健康检查,收集工作现场有害物质情况和中毒患者临床资料,分析中毒原因和致病特征。结果触摸屏防指纹纳米涂层材料"防指纹油"挥发性组分占空气相对含量为85.65%(检测温度45℃),挥发性有机组分主要为有机氟类,包括全氟二甲基环己烷(18.72%)、全氟庚烷(5.78%)、全氟己烷(26.98%)、全氟甲基戊烷(0.75%)、全氟-2-甲基-2-戊烯(15.48%);有机氟接触组员工脱离接触5~6 d,尿氟平均浓度为13.7±4.4 mmol/mol肌酐,为非接触组4~5倍;与非接触组员工比较,有机氟接触组员工尿氟水平差异有统计学意义(P<0.01)。4例急性有机氟中毒患者临床表现为急性支气管炎、肺水肿和(或)心肌炎等;辅助检查主要以吸空气下指脉血氧饱和度、白细胞、中性粒细胞、单核细胞、超敏C反应蛋白、降钙素原、L-乳酸脱氢酶、前脑利尿钠肽、高敏肌钙蛋白T异常改变为主。其中,心肌缺血1例,双肺对称渗出性病变4例,伴胸腔心包腔少量积液1例。结论手机触摸屏防指纹纳米涂层材料应用可致有机氟急性中毒,应重视小分子全氟烷(烯)烃类在新行业、新工艺和新材料应用导致的职业中毒。Objective To analysis pathogenic conditions and pathogenic characteristics of organic fluorosis caused by applying of anti-fingerprint coating material on touch screen glass of the mobile phone.Methods To collect clinical data and analyze the causes and pathogenic characteristics of poisoning through surveying occupational health,detecting occupational hazards in the workplace,collecting clinical data and diagnosing of occupational diseases.6 employees in workshop 1 of packaging were as the organic fluorine exdposed group,and 16 employees in other workshops were as the non-exposed group.Results Organic fluorine chemicals(perfluoro-1,3-dimethylcyclohexane,hexadecafluoroheptane,perfluoro-hexane,perfluoromethy lopentane,perfluoro-2-methyl-2-pentene,etc.)can be volatilized by spraying and baking of anti-fingerprint nano-coating material on touch screen.The relative percentage of volatile components in air is 85.65%.Four cases of acute poisoning were caused by organic fluorosis deposited in a dustless air conditioning workshop with poor ventilation.The clinical manifestations of the patients were acute bronchitis,pulmonary edema and/or myocarditis.The average concentration of urine fluorine in the organic fluorine exposed group was 13.7±4.4 mmol/mol creatinine,which was 4-5 times higher than that of other non-organic fluorine exposed groups.The difference of urine fluorine level between the organic fluorine exposed group and non exposed group was statistically significant(P<0.01).The main indicators were abnormal for the blood oxygen saturation of finger pulse under suction air,leukocytes,neutrophils,monocytes,hypersensitivec-reactive protein,procalcitonin,l-lactate dehydrogenase,forebrain diuretic natriuretic peptide,hypersensitive troponin T in the four cases.One case was myocardial ischemia,four cases had bilateral lung symmetrically exudative lesions,one case was accompanied by a small amount of pleural pericardial effusion.Conclusion Acute organofluorine poisoning can caused by the applying of the fingerprint na

关 键 词：有机氟中毒 防指纹纳米涂层 劳动条件 致病特征 

分 类 号：R1[医药卫生—公共卫生与预防医学]