原络配穴法结合四磨汤治疗功能性消化不良的临床研究  

Effect of Origin Collateral Acupoint Matching Method Combined with Simo Decoction(四磨汤) on Functional Dyspepsia

作　　者：梁菲 邓斌[2] 陈雅文 LIANG Fei;DENG Bin;CHEN Ya-wen(l.The Fifth Affiliated Hospital of Guangzhou Medical University,Guangzhou Guangdong 510700,China;The Eastern Hospital of The First Affiliated Hospital,Sun Yat-sen University,Guangzhou Guangdong 510700,China;Guangzhou Liwan District Hospital of Traditional Chinese Medicine,Guangzhou Guangdong 510160,China)

机构地区：[1]广州医科大学附属第五医院,广东广州510700 [2]中山大学附属第一医院东院,广东广州510700 [3]广州市荔湾区中医医院,广东广州510160

出　　处：《中医药导报》2019年第24期31-35,共5页Guiding Journal of Traditional Chinese Medicine and Pharmacy

基　　金：广东省中医药管理局面上科研项目（201700240），项目名称：原络配穴法结合四磨汤对功能性消化不良患者的临床研究

摘　　要：目的:观察原络配穴法结合四磨汤治疗功能性消化不良(FD)的疗效及对患者中医证候积分、生化指标及生活质量的影响。方法:选取116例FD患者,按随机数字表法分为治疗组和对照组各58例。对照组患者予口服多潘立酮片,治疗组患者予原络配穴法针刺结合口服四磨汤,疗程14 d。观察治疗前后两组患者中医证候积分、生活质量评分及血清乙酰胆碱酯酶(AchE)、血浆胃动素(MTL)、血清胆囊收缩素(CCK)、一氧化氮(NO)、血浆生长抑素(SS)的变化,并观察两组临床疗效和不良反应发生情况。结果:治疗组总有效率(98.28%)高于对照组(89.66%),差异有统计学意义(P<0.05)。两组患者治疗后中医证候积分均较治疗前降低(P<0.05),且治疗组患者治疗后中医证候积分低于对照组(P<0.05)。两组患者治疗后AchE、MTL均较治疗前升高(P<0.05),且治疗组患者治疗后AchE、MTL均高于对照组(P<0.05);两组患者治疗后CCK、NO、SS均较治疗前降低(P<0.05),且治疗组患者治疗后CCK、NO、SS均低于对照组(P<0.05)。对照组患者治疗结束2个月后社会功能(SF)和生理职能(RP)评分均较治疗前升高(P<0.05),治疗组患者治疗结束2个月后精神健康(MH)、情感职能(RE)、SF、活力(VT)、总体健康(GH)、RP评分及总评分均较治疗前升高(P<0.05);治疗组患者治疗结束2个月后MH、RE、SF、VT、GH、RP评分及总评分均高于对照组(P<0.05)。治疗组患者不良反应发生率(10.34)低于对照组(1.72%),差异有统计学意义(P<0.05)。结论:原络配穴法结合四磨汤治疗FD疗效确切,安全可靠,能够降低患者中医证候积分,促进患者胃肠蠕动,提高患者生活质量。Objective: To explore the curative effect of origin collateral acupoint matching method combined with Simo decoction on functional dyspepsia(FD) and its influence on TCM symptom score, biochemical index and quality of life. Methods: The 116 FD patients were divided into treatment group(n=58) and control group(n=58) according to random number table method. The control group was treated with oral domperidone tablets.The treatment group was treated with the origin collateral acupoint matching method combined with Simo decoction. The clinical effects of the two groups were analyzed. The scores of TCM symptoms, laboratory tests before treatment and 14 days after treatment were compared between the two groups;the quality of life score before treatment and 2 months after treatment were compared between the two groups, and the occurrence of adverse reactions was observed. Results: The total effective rate of the treatment group(98.28%) was higher than that of the control group(89.66%)(P<0.05). The scores of TCM syndrome in the two groups were lower than those before treatment(P<0.05), and the scores of TCM syndrome in the treatment group were lower than those in the control group(P<0.05). After treatment, AchE and MTL in the two groups were higher than those before treatment(P<0.05), and AchE and MTL in the treatment group were higher than those in the control group(P<0.05);CCK, NO and SS in the two groups were lower than those before treatment(P<0.05), and CCK, NO and SS in the treatment group were lower than those in the control group(P<0.05). The scores of social function(SF) and physiological function(RP) in the control group were higher than those before treatment(P<0.05), and the scores of mental health(MH), emotional function(RE), SF, vitality(VT), overall health(GH), RP and total score in the treatment group were higher than those before treatment(P<0.05). The scores of MH, RE, SF, VT, GH and RP in the treatment group were higher than those in the control group(P<0.05). The incidence of adverse reactions in the t

关 键 词：功能性消化不良 原络配穴法 四磨汤 针药结合 中医证候积分 生化指标 生活质量 

分 类 号：R246.1[医药卫生—针灸推拿学]