纳米氧载体的设计及其在肿瘤诊疗中的应用  

Design of Nano-Oxygen Carrier and Its Application in Tumor Diagnosis and Treatment

作　　者：于朋 野庆松 吴锦慧[1,2] YU Peng;YE Qingsong;WU Jinhui(School of Medicine,Nanjing University,Nanjing 210093,China;Chemistry and Biomedicine Innovation Center,NanjingUniversity,Nanjing 210023,China)

机构地区：[1]南京大学医学院,江苏南京210093 [2]南京大学化学和生物医药创新研究院,江苏南京210023

出　　处：《药学进展》2019年第11期841-855,共15页Progress in Pharmaceutical Sciences

基　　金：国家重点研发计划（No.2017YFA0205400）;国家自然科学基金（No.31872755）;江苏省杰出青年基金（No.BK20190007）

摘　　要：乏氧普遍存在于多种实体肿瘤中,极易导致抗肿瘤治疗(如:化疗、放疗、光动力治疗、声动力治疗等)的失败,并最终引起肿瘤的恶化和转移。近年来,许多新兴的纳米技术不断涌现,并被用于改善肿瘤乏氧,从而降低治疗耐受的发生。现有的纳米氧载体主要通过向肿瘤直接递送氧气或与肿瘤微环境反应产生氧气来实现供氧。从纳米氧气载体的设计及其在肿瘤诊疗中的应用2个方面,综述近5年纳米技术在肿瘤供氧方面的研究进展,以期为相关研究提供参考。Hypoxia,which is common in a variety of solid tumors,can easily lead to the failure of anti-tumor treatments(such as chemotherapy,radiotherapy,light therapy,sonodynamic therapy,etc.),and may eventually lead to the deterioration and metastasis of tumor.In recent years,many new nanotechnologies have emerged and have been used to reverse tumor hypoxia,thereby reducing the occurrence of treatment resistance.The existing nano-oxygen carriers mainly directly include delivering oxygen to the tumor and generating oxygen in situ.This review summarizes the research progress of nanotechnology in tumor oxygen supply in the past five years from the design of nano-oxygen carrier and its application in tumor diagnosis and treatment,in order to provide references for related research.

关 键 词：乏氧 纳米氧载体 肿瘤进展 肿瘤转移 治疗抗性 成像 治疗 

分 类 号：R943[医药卫生—药剂学]