酞丁安的微量杂质分析和形成机理  

Analysis and Formation Mechanism of Specified Impurity in Ftibamzone

作　　者：钱莉苹 黄勇 唐英武 吴世刚 QIAN Li-ping;HUANG Yong;TANG Ying-wu;WU Shi-gang(Hefei Yifan Biopharmaceutical Co.,Ltd.,Hefei 230000,China)

机构地区：[1]合肥亿帆生物制药有限公司

出　　处：《精细化工中间体》2019年第5期29-32,共4页Fine Chemical Intermediates

摘　　要：根据酞丁安的生产工艺和合成反应机理,分析可能存在的特定杂质。对抗病毒药酞丁安(Ftibamzone)产品中的微量杂质进行了富集与提纯,运用质谱、核磁共振等技术对其进行了分析,确定杂质为关键中间体过渡态氧化未完全物继续缩合形成的一缩硫脲。通过化学合成该杂质,探讨了该杂质的形成机理。To evaluate probably existed specified impurities of Ftibamzone according to the production process and synthetic reaction mechanism of Ftibamzone the specified impurity in Ftibamzone was enriched and purified.The structure of the impurity was identified by HPLC-MS,1 H NMR,13 C NMR, and it was a thiourea from condensation of the oxidation-incomplete key intermediate transition state, and the formation mechanism of the impurity was discussed.

关 键 词：酞丁安 合成 机理 特定杂质 

分 类 号：R978.7[医药卫生—药品]