山西地区糖调节受损患者脂联素基因SNP276多态性与原发性高血压的关系  

Association of SNP276 polymorphism in adiponectin gene with essential hypertension in population of Shanxi region with impaired glucose regulation

作　　者：范雪梅[1] 郗光霞[1] 赵凌霞[1] 杨坤[1] 高林琳[1] Fan Xuemei;Xi Guangxia;Zhao Lingxia;Yang Kun;Gao Linlin(Department of Endocrinology,Shanxi Academy of Medical Sciences,Shanxi Bethune Hospital,Taiyuan 030032 China)

机构地区：[1]山西医学科学院山西白求恩医院内分泌科,太原030032

出　　处：《中国医师杂志》2020年第1期29-32,共4页Journal of Chinese Physician

基　　金：山西省卫生计生委科研课题(2014002)。

摘　　要：目的探讨中国山西地区糖调节受损(IGR)汉族人群脂联素基因(APM1)单核苷酸多态性(SNP)276G/T与原发性高血压的关系。方法采用聚合酶链反应-限制性内切酶长度多态性(PCR-RFLP)技术对无亲缘关系的山西地区汉族人群中216例糖调节受损者的APM1 SNP276进行基因分型,探讨其与原发性高血压的关系。结果IGR无高血压组及IGR合并高血压组AMP1基因型及等位基因分布差异有统计学意义(P=0.025,P=0.007),与TT型相比,GG+GT型IGR患者合并原发性高血压的风险增加(OR=3.346,95%CI:1.115~8.986,P=0.037),经性别、年龄及BMI校正后,风险增加无统计学意义(P=0.349)。结论脂联素基因SNP276 G/T与山西地区汉族人IGR合并原发性高血压有关,但非独立相关。Objective To study the association of single nucleotide polymorphism(SNP)276 in adiponectin gene with essential hypertension in population with impaired glucose regulation in Han people of Shanxi region.Methods The study population consisted of 216 Chinese Hans residents with impaired glucose regulation(IGR)in Shanxi province.Polymerase chain reaction-restriction fragment length polymorphism(PCR-RFLP)was applied to test the adiponectin SNP276G/T polymorphism.Results The distributions of genotypes and alleles of SNP276 both displayed significant difference between the IGR complicating norm tension group and the hypertension group(P=0.025,P=0.007).Compared with the TT genotype,the SNP276 non-TT(GT+GG)genotype was associated with increased risk of complicating with hypertension(OR=3.346,95%CI:1.115-8.986,P=0.037),while after age-,sex-and BMI-adjusted,there was no significant difference between the 2 groups(P=0.349).Conclusions SNP276 in adipose most abundant gene transcript 1(APM1)was associated with the susceptibility to be complicating essential hypertension in population with impaired glucose regulation in Han people of Shanxi region.

关 键 词：脂联素 多态性 单核昔酸 糖调节受损 高血压 

分 类 号：R587.1[医药卫生—内分泌] R544.11[医药卫生—内科学]