宁波市手足口病患者密切接触人群肠道病毒检出情况及影响因素分析  

Detection of enterovirus and its influencing factors among individuals having in close contact with hand-foot and mouth disease patients in Ningbo city

作　　者：丁克琴[1] 易波[1] 陈奕[1] 焦素黎[1] 董红军[1] 许国章[1] DING Ke-qin;YI Bo;CHEN Yi(Ningbo Municipal Center for Disease Control and Prevention,Ningbo,Zhejiang Province 315010,China)

机构地区：[1]宁波市疾病预防控制中心

出　　处：《中国公共卫生》2020年第1期92-95,共4页Chinese Journal of Public Health

基　　金：浙江省医学重点学科（07–013）;宁波市市级医疗卫生品牌学科（PPXK2018–10）

摘　　要：目的了解浙江省宁波市手足口病患者密切接触人群肠道病毒携带情况及其影响因素,为手足口病的防控提供参考依据。方法采集2016年1月-2017年12月宁波慈溪市、余姚市和奉化区手足口病患者密切接触人群的1097份标本进行了肠道病毒核酸检测。结果宁波市2016-2017年采集的1097份手足口病患者密切接触人群标本中,检出肠道病毒207份,肠道病毒检出率为18.87%;其中分别检出肠道病毒71型(EV-A71)、柯萨奇病毒A组16型(CV-A16)和其他肠道病毒29、56和122份,检出率分别为2.64%、5.10%和11.12%。多因素非条件logistic回归分析结果显示,手足口病患者密切接触人群肛拭子和咽拭子较粪便标本肠道病毒检出率低;流行季节为4-7月和接触患者病原学检测结果为阳性的手足口病患者密切接触人群肠道病毒检出率较高。结论手足口病密切接触人群肠道病毒携带率较高,标本类型、流行季节和接触患者病原检测结果是手足口病患者密切接触人群肠道病毒检出情况的主要影响因素。Objective To examine enterovirus infection rate and its influencing factors among close contacts of hand-foot and mouth disease(HFMD)patients in Ningbo city and to provide evidences for HFMD prevention and control.Methods We collected totally 1097 feces and throat/anal swab specimens from 366 close contacts of HFMD patients in Cixi and Yuyao prefecture and Fenghua distirct of Ningbo municipality during the period from January 2016 to December 2017.Enterovirus nucleic acid was detected for all the specimens.Results Of all the specimens,207 were positive for enterovirus nucleic acid,with a detection rate of 18.87%.The number of positive specimens(detection rate)were 29(2.64%),56(5.10%),and 122(11.12%)for enterovirus A71(EV-A71),Coxsackie virus A16(CV-A16),and the other enterovirus,respectively.Multivariate unconditional logistic regression analysis indicated that anal and throat swab specimens were less likely to be enterovirus positive compared to feces specimens and specimens collected during epidemic season from April to July in a year were more likely to be enterovirus positive in comparison with the specimens collected in other seasons.Conclusion The enterovirus detection rate is high and mainly influenced by type of the specimens collected,the time of specimen sampling and detection result of other pathogens among close contacts of HFMD patients in Ningbo city.

关 键 词：肠道病毒 手足口病 密切接触人群 影响因素 

分 类 号：R373.23[医药卫生—病原生物学]