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作 者:张海军[1] 覃开蓉 申华[3] 李泳江 ZHANG Hai-jun;QIN Kai-rong;SHEN Hua;LI Yong-jiang(School of Biomedical Engineering,Dalian University of Technology,Dalian 116024,China;School of Optoelectronic Engineering and Instrumentation Science,Dalian University of Technology,Dalian 116024,China;School of Intelligence&Electronic Engineering,Dalian Neusoft University of Information,Dalian 116024,China)
机构地区:[1]大连理工大学生物医学工程学院,大连116024 [2]大连理工大学光电工程与仪器科学学院,大连116024 [3]大连东软信息学院智能与电子工程学院,大连116024
出 处:《水动力学研究与进展(A辑)》2019年第6期726-733,共8页Chinese Journal of Hydrodynamics
基 金:国家自然科学基金项目(31370948);中央高校基本科研业务费项目(DUT19ZD201,DUT18RC(3)030)~~
摘 要:血流动力学参数不仅在运动调控动脉结构和功能的过程中扮演重要的角色,而且是评估心血管功能的重要生理指标。血流电阻抗监测技术因为便携、可穿戴和微型化等优点,便于运动过程中血流动力学参数的在线监测。然而,由于运动前后血流电导率、电阻抗和血流动力学参数之间的定量关系仍未完全阐明,阻碍了这一技术在血流动力学监测中的广泛应用。该文采用运动干预实验、数值模拟及统计学相关性分析方法,研究了运动前后血流动力学参数的变化规律及其与血流电导率和电阻抗之间的定量关系。结果显示,急性有氧自行车运动对颈总动脉血压、管径、轴心流速和电阻抗影响显著,对电导率影响较小;电导率波形主要受轴心流速波形影响,与轴心流速成线性关系,而电阻抗波形主要受动脉半径波形影响,与动脉半径平方的倒数成线性关系。该文的研究结果为进一步开发基于血流动力学参数监测评估心血管功能的可穿戴医疗设备提供了一定的理论基础。Hemodynamic variables not only play important roles in the process of exercise-modulated arterial structure and function,but also are important physiological indicators for assessing cardiovascular function.Owing to the advantages of portability,wearable ability and miniaturization,the electrical impedance monitoring technology facilitates on-line monitoring of hemodynamic variables during exercise.However,the quantitative relationship between the blood conductivity or the electrical impedance and hemodynamic variables before and after exercise has not been fully elucidated,hindering the wide use of this technique in hemodynamic monitoring.In this paper,exercise intervention experiments,numerical simulations and statistical correlation analysis methods were used to study the changes of hemodynamic variables before and after exercise and their quantitative relationship with the blood conductivity and the electrical impedance.The results show that acute aerobic exercise by bicycle has significant effects on the common carotid artery blood pressure,diameter,center-line velocity,and electrical impedance,but contributes little to the conductivity.The conductivity waveform is mainly determined by the waveform of the center-line velocity,and its value is linearly related to the center-line velocity.The electrical impedance waveform is primarily affected by the arterial radius waveform and its value is proportional to the reciprocal of radius squared.The results of this study provide a theoretical basis for further development of wearable medical devices based on monitoring hemodynamic variables to assess cardiovascular function.
分 类 号:R318.01[医药卫生—生物医学工程]
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