植物化学物山竹子素的抗癌效应及其机制研究进展  

Advances on anti-cancer effects and mechanisms of phytochemical garcinol

作　　者：沈愁 徐新明[1] 陆荣柱[2] 陈健[1] SHEN Chou;XU Xin-ming;LU Rong-zhu;CHEN Jian(Department of Hepatobiliary Surgery,Kunshan Hospital A Affiliated to Jiangsu University,Suzhou,Jiangsu 215300,China;Medical College of Jiangsu University,Zhenjiang,Jiangsu 212013,China)

机构地区：[1]江苏大学附属昆山医院肝胆外科,江苏苏州215300 [2]江苏大学医学院,江苏镇江212013

出　　处：《环境与职业医学》2019年第12期1175-1181,共7页Journal of Environmental and Occupational Medicine

基　　金：昆山市科技计划项目(KS18055)

摘　　要：山竹子素是从山竹果壳中提取出来的一种植物化学物质,其结构为聚异戊二烯化的二苯甲酮。大量研究表明,山竹子素对头颈癌、肺癌、乳腺癌、肝癌、胰腺癌、结肠癌、前列腺癌等肿瘤有抗癌功效,其抗癌效应可能与抗氧化、抗炎、抑制肿瘤细胞增殖、诱导凋亡、抑制自噬作用有关。研究发现,多种与炎症和肿瘤相关的信号通路及生物分子,如NF-κB、STAT、Akt、Wnt、MAPK和COX等参与到山竹子素的抗癌效应中。现有研究表明,山竹子素因其高效抗肿瘤和对正常细胞低毒的特性可作为一种有前途的抗肿瘤药物,但仍需在相关癌症的体外实验及动物模型中开展研究,为其药物研发及临床应用打下基础。Garcinol is the principle bioactive compound derived from the rind of the fruiting bodies of Garcinia indica.Its structure is polyprenylated benzophenone.A variety of studies have shown that it has anti-cancer effects on head and neck cancer,lung cancer,breast cancer,hepatocellular carcinoma,pancreatic cancer,colon cancer,prostate cancer,and other tumors,and such effects may be related to anti-oxidation,anti-inflammation,cell proliferation suppression,induction of apoptosis,and inhibition of autophagy.Studies have shown a variety of signaling pathways related to inflammation and tumors:NF-κB,STAT,Akt,Wnt,MAPK,and COX,for instance,are involved in the anti-cancer effects of garcinol.Available studies have shown that garcinol can be a promising anti-tumor drug because of its high anti-cancer therapeutic efficacy and low toxicity to normal cells;however,more in vitro and animal experiments of related cancers are necessary to lay the foundation for its drug research and development and clinical application.

关 键 词：山竹子素 植物化学物 抗癌 信号通路 

分 类 号：R1[医药卫生—公共卫生与预防医学]