星点设计-效应面法优化盐酸川芎嗪鼻用凝胶剂的处方及其体外释放行为研究  

Optimization of Ligustrazine Hydrochloride Nasal Gel Formulation by Central Composite DesignResponse Surface Method and Study on the Drug Release Behavior in vitro

作　　者：郝晶 王小宁[1] 闫梦茹 马远涛[1] 梁晓燕[1] HAO Jing;WANG Xiao-ning;YAN Meng-ru;MA Yuan-tao;LIANG Xiao-yan(Xi'an Medical University,Xi'an 710021,China)

机构地区：[1]西安医学院药学院

出　　处：《化学与粘合》2020年第1期13-15,35,共4页Chemistry and Adhesion

基　　金：陕西省科技厅面上项目（编号：2018JM7092);2018年省级大学生创新创业训练项目计划项目汇总表（编号：201825055）;陕西省教育厅专项科学研究计划（编号：19JK0757）;陕西省缺血性心血管疾病重点实验室开放基金项目（编号：2017ZDKF09）;中尼友好拉吉姆医学实验室开放基金项目（编号：18LJM06)

摘　　要：优化盐酸川芎嗪鼻用凝胶剂处方,对其体外释放行为进行考察。以卡波姆934和羟丙基甲基纤维素HPMC为凝胶基质,以黏度为评价指标,通过星点设计-效应面法优化凝胶处方,透析法进行体外释药特性评价,并对释放曲线进行拟合,探讨体外释放行为。结果表明,最优处方为卡波姆浓度为1.0%、HPMC浓度为1.9%,凝胶黏度平均值为4.85Pa·s,体外释药结果显示,盐酸川芎嗪鼻用凝胶表现出明显的缓释特性,释放过程符合Weibull模型。The purpose of this work is to optimize the formulation of ligustrazine hydrochloride nasal gel and to investigate its release behavior in vitro. The gel prescription is optimized by central composite design-response surface method with carbomer 934 and hydroxypropyl methylcellulose HPMC as the gel matrix, and the viscosity as the evaluation index. The in vitro release characteristics are evaluated by dialysis method, and the re-lease curve is fitted to investigate the in vitro release behavior. The optimal prescription is obtained as follows: the carbomer and HPMC concentration is 1.0% and 1.9% respectively, and the average gel viscosity is 4.85 Pa·s. The in vitro release results show that the ligustrazine hydrochloride nasal gel exhibits significant sustained-release properties, and the release process conforms to the Weibull model.

关 键 词：盐酸川芎嗪 鼻用凝胶 星点设计-效应面法 体外释放 

分 类 号：TQ469[化学工程—制药化工] R944.2[医药卫生—药剂学]