基于短声和扫频音的听觉脑干诱发电位比较研究  

A Comparison Study on Auditory Brainstem Responses Induced by Click and Swept-Tone

作　　者：姜言冰[1,2] 薛金伟 汪鑫 孙淑睿 王程 陈世雄 李光林[1] JIANG Yanbing;XUEJinwei;WANG Xinu;SUN Shurui;WANG Cheng;CHEN Shixiong;LI Guanglin(CAS Key Laboratory of Human-Machine Intelligence-Synergy Systems,Shenzhen Institutes of Advanced Technology,Chinese Academy of Sciences,Shenzhen 518055,China;Shenzhen College of Advanced Technology,University of Chinese Academy of Sciences,Shenzhen 518055,China;Institute of Pharmacy and Bioengineering,Chongqing University of Technology,Chongqing 400054,China)

机构地区：[1]中国科学院深圳先进技术研究院人机智能协同系统重点实验室,深圳518055 [2]中国科学院大学深圳先进技术学院,深圳518055 [3]重庆理工大学药学与生物工程学院,重庆400054

出　　处：《集成技术》2020年第1期28-35,共8页Journal of Integration Technology

基　　金：深圳市基础研究学科布局项目(JCYJ20180507182241622);广州市科技计划项目(201803010093);国家自然科学基金项目(61771462)

摘　　要：听觉脑干诱发电位检测(Auditory Brainstem Response,ABR)是一种客观检测听力损失的常用方法。短声作为一种宽频信号,其诱发的ABR通常被认为是ABR检测的金标准。但由于人体耳蜗基底膜行波具有延迟特性,短声不能同时刺激整个耳蜗基底膜产生兴奋,导致诱发的ABR波形因不同相而产生衰减。为解决这一局限性,该研究设计了一种扫频音刺激,根据耳蜗基底膜的延迟特性重新调整不同频率成分出现的时间,以诱发ABR信号。实验通过将所设计的扫频ABR方法和传统的短声ABR方法的波质量进行比较发现,在不同的刺激强度和刺激速率下,扫频ABR的波形形态均明显优于短声ABR的。此外,在不同的响应叠加次数下,所设计的扫频音比短声诱发ABR能更快地诱发出ABR波形。该文所提出的扫频ABR方法有望提高ABR在听力损失诊断中的灵敏度。The auditory brainstem response(ABR)is an objective method to detect hearing loss.Generally,the ABR induced by click is considered as the gold standard.However,the click-induced ABR is mainly used to assess high-frequency hearing due to the delayed characteristics of human cochlear basilar membrane.In order to compensate for the limitation of the ABR induced by click,a swept-tone stimulus that adjusts the occurrence time of different frequency components was proposed and used to evoke the ABR in this study.The swept-tone evoked ABR was compared with the click evoked ABR at different test levels and different stimulus rates.The experimental results show that the waveform morphology of the swept-tone ABR is better than that of the click ABR.In addition,the swept-tone ABR and the click ABR after different sweeps were also calculated under a different number of sweeps,and the results show that the swept-tone ABR could save recording time compared to the click ABR.These results suggest that the proposed swept-tone ABR could be more sensitive than the commonly used click ABR in the detection of hearing loss.

关 键 词：听觉脑干诱发电位 短声 扫频音 

分 类 号：R764.04[医药卫生—耳鼻咽喉科]