肝硬化上消化道出血与血小板参数、脾脏厚度及凝血功能的相关研究  

Related study on platelet parameters, spleen thickness and coagulation function in patients with upper gastrointestinal hemorrhage in cirrhosis

作　　者：包文 万志红 宋晨 BAO Wen;WAN Zhi-hong;SONG Chen(Department of Gastroenterology,People′s Hospital in Ganxian District of Ganzhou City,Jiangxi Province,Ganzhou341100,China)

机构地区：[1]江西省赣州市赣县区人民医院消化内科

出　　处：《中国当代医药》2020年第4期40-42,46,共4页China Modern Medicine

基　　金：江西省赣州市指导性科技计划项目(GZ2017ZSF388)

摘　　要：目的分析肝硬化上消化道出血患者的血小板(PLT)参数、脾脏厚度及凝血功能指标。方法选取2016年1月~2018年1月我院肝胆科收治的75例肝硬化患者作为对照组。选取我院同期收治的75例肝硬化上消化道出血患者作为观察组。对所有患者开展血常规、凝血功能及脾脏厚度检测。比较两组患者的PLT参数、脾脏厚度及凝血功能差异。结果观察组患者的平均血小板体积(MPV)、大型血小板比例(P-LCR)低于对照组,差异有统计学意义(P<0.05);观察组患者的脾厚数值高于对照组,PLT/脾厚指数低于对照组,差异有统计学意义(P<0.05);观察组患者的凝血酶原时间(PT)、活化部分凝血活酶时间(APTT)长于对照组,差异有统计学意义(P<0.05)。结论肝硬化上消化道出血患者的PLT参数、凝血指标均较差,PLT/脾厚明显降低,对于临床判断肝硬化患者是否并发上消化道出血具有指导意义。Objective To analyze the platelet(PLT)parameters,spleen thickness and coagulation function indicators in patients with upper gastrointestinal hemorrhage in cirrhosis.Methods From January 2016 to January 2018,75 patients with cirrhosis admitted to the department of hepatobiliary in our hospital were selected as the control group,and 75 patients with upper gastrointestinal hemorrhage in cirrhosis admitted to our hospital during the same period were selected as the observation group.All patients are tested in platelet parameters,spleen thickness and coagulation function.Differences in the PLT parameters,spleen thickness and coagulation function between two groups were compared.Results The mean platelet volume(MPV)and the large platelet ratio(P-LCR)in the observation group were lower than those in the control group,with statistically significant differences(P<0.05).The value of splenic thickness in the observation group was higher than that in the control group,and the PLT/splenic thickness index was lower than that in the control group,with statistically significant differences(P<0.05).The prothrombin time(PT)and activated partial thromboplastin time(APTT)in the observation group were longer than those in the control group,and the differences were statistically significant(P<0.05).Conclusion Patients with upper gastrointestinal hemorrhage in cirrhosis have poor platelet parameters and coagulation parameters,and PLT/spleen thickness is significantly reduced.It is of significance for guiding clinical judgment of cirrhosis patients complicated with upper gastrointestinal hemorrhage or not.

关 键 词：血小板参数 脾脏厚度 凝血功能 肝硬化上消化道出血 

分 类 号：R282.71[医药卫生—中药学]