支气管肺发育不良的表观遗传学机制研究进展  

Epigenetic mechanisms of bronchopulmonary dysplasia:a review

作　　者：陈佩娟 万致婷[2] 蔡保欢 李文斌[1] Chen Peijuan;Wan Zhiting;Cai Baohuan;Li Wenbin(Department of Pediatrics,Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430030,China;Department of Pediatrics,Xianning Central Hospital,First Affiliated Hospital of Hubei University of Science and Technology,Xianning 437100,China)

机构地区：[1]华中科技大学同济医学院附属同济医院儿科,武汉430030 [2]湖北省咸宁市中心医院,湖北科技学院附属第一医院新生儿科,437100

出　　处：《中华围产医学杂志》2020年第1期56-60,共5页Chinese Journal of Perinatal Medicine

基　　金：国家自然科学基金应急管理项目(81741099);国家自然科学基金青年科学基金项目(81601328);湖北省自然科学基金资助项目(2014CFC1027);湖北省卫生计生委面上项目(WJ2017M251)。

摘　　要：支气管肺发育不良是早产儿常见的慢性呼吸系统并发症,其发病机制尚未完全阐明,且暂无有效防治措施,严重影响早产儿存活率及预后。已有研究证实,组蛋白修饰、非编码RNA和DNA甲基化等表观遗传学机制在支气管肺发育不良的发生、发展过程中发挥重要作用,且相关表观遗传变化多为可逆性改变,可能为临床治疗提供重要靶点。因此,表观遗传学研究将为进一步认识支气管肺发育不良的发病机制及防治支气管肺发育不良提供新方向和思路。Bronchopulmonary dysplasia(BPD)is a common chronic respiratory complication in preterm infants without fully understand the mechanism or effective treatment,which could significantly affect the survival rate and prognosis of these infants.Studies have confirmed that epigenetic mechanisms,including histone modification,non-coding RNA and DNA methylation may play an essential role in the onset and development of BPD.And most related epigenetic changes are reversible,which might serve as a potential target for BPD treatment.Therefore,further studies on epigenetics will shed light on a better understanding of the pathogenesis,prevention,and treatment of BPD.

关 键 词：支气管肺发育不良 表观基因组学 组蛋白密码 RNA 未翻译 DNA甲基化 

分 类 号：R722.6[医药卫生—儿科]