声辐射力脉冲成像超声定量检测评估儿童脂肪肝应用价值探讨  

Quantitative evaluation of nonalcoholic fatty liver in children by acoustic radiation force pulse imaging

作　　者：叶细容 吕志洪 解育新 江峰[2] Ye Xirong;Lyu Zhihong;Xie Yuxin(Department of Ultrasound,Affiliated Hospital,Hubei college of science and engineering,Huangshi 435000,Hubei Province,China)

机构地区：[1]湖北理工学院附属医院超声影像科,湖北省黄石市435000 [2]皖南医学院附属弋矶山医院超声影像科

出　　处：《实用肝脏病杂志》2020年第2期223-226,共4页Journal of Practical Hepatology

基　　金：湖北省自然科学基金资助项目(编号:2015FFB04310)

摘　　要：目的研究声辐射力脉冲成像技术(ARFI)定量检测评估儿童非酒精性脂肪肝(NAFL)的应用价值。方法2015年4月~2019年1月我院诊治的92例NAFL患儿和120例正常儿童,均使用ARFI技术测量肝脏剪切波速度(SWV)。采用ROC曲线确定SWV的最佳诊断截断点,并评价其对儿童NAFL的诊断价值。结果NAFL患儿SWV值为(1.3±0.2)m/s,显著高于对照组[(0.8±0.2)m/s,P<0.01];36例轻度NAFL患儿SWV值为(1.1±0.1)m/s,显著低于31例中度NAFL患儿[(1.2±0.1)m/s,P<0.01]或25例重度NAFL患儿[(1.4±0.3)m/s,P<0.01],中度NAFL患儿SWV值显著低于重度NAFL患儿(P<0.01);经ROC曲线分析,结果显示SWV值诊断NAFL的最佳截断点为1.09 m/s,其诊断的曲线下面积为0.836,诊断的敏感度为0.826,特异度为0.850。结论应用ARFI技术能准确无创定量评价NAFL及其严重程度,对儿童筛查脂肪肝有重要的临床意义。Objective The aim of this study was to study the application of acoustic radiation force impulse imaging(ARFI)in quantitative assessment of nonalcoholic fatty liver(NAFL)in children.Methods 92 children with NAFL and 120 health children were enrolled in our hospital between April 2015 and January 2019,and all were checked-up by acoustic radiation force impulse imaging technology for the shear wave velocity(SWV).The diagnosticefficacy was analyzed by the area under ROC(AUC).Results The SWV in children with NAFL was(1.3±0.2)m/s,significantly higher than[(0.8±0.2)m/s,P<0.01]in healthy children;the SWV in 36 children with mild NAFL was(1.1±0.1)m/s,significantly lower than[(1.2±0.1)m/s,P<0.01]in 31 children with moderate NAFL or[(1.4±0.3)m/s,P<0.01]in 25 children with severe NAFL(P<0.01);the AUC analysis showed that the optimal cut-off-value for diagnosis of NAFL by SWV was 1.09 m/s,with the AUC of being 0.836,sensitivity of 0.826,and specificity of 0.850.Conclusion The application of ARFI could accurately and quantitatively evaluate NAFL in children,and it plays an important role in the early screening of ARFI.

关 键 词：非酒精性脂肪肝 声辐射力脉冲成像技术 诊断 儿童 

分 类 号：R445.1[医药卫生—影像医学与核医学] R725.7[医药卫生—诊断学]