血清铁调素-25水平与2型糖尿病肾病中肾功能不良进展的相关性研究  

The analysis of the correlation between serum hepcidin-25 and poor progression of diabetic nephropathy in type 2 diabetes patients

作　　者：刘岳鹏 LIU Yuepeng(Central Laboratory,Xuzhou Central Hospital,Xuzhou,Jiangsu 221000,China)

机构地区：[1]徐州市中心医院中心实验室

出　　处：《国际检验医学杂志》2020年第5期532-535,共4页International Journal of Laboratory Medicine

基　　金：国家自然科学基金项目(81671084)

摘　　要：目的分析血清铁调素-25与2型糖尿病肾病中肾功能不良进展之间是否具有相关性。方法该研究试验设计为巢式病例对照设计,220例患者资料来源于2015年4月至2019年6月在徐州市中心医院住院的2型糖尿病肾病患者。血清铁调素-25水平采用ELISA法检测,以肾功能不良进展(肾替代疗法或血清肌酐加倍)作为结局指标。采用多因素Cox回归分析为主要的分析方法,配合以肾小球滤过率(GFR)为分层因素的分层分析。结果Cox分析显示血清铁调素-25水平与2型糖尿病所致的慢性肾病患者的肾功能不良进展之间不具有相关性(HR=1.18,95%CI:0.97~1.45)。分层分析显示GFR是以上关系的效应修饰因素:GFR低[<51.8 mL/(min·1.73 m 2)]时,血清铁调素-25水平与2型糖尿病肾病不良进展之间呈正相关(HR=2.56,95%CI:1.50~4.40),而GFR高的时候,血清铁调素-25水平与2型糖尿病肾病不良进展之间呈负相关(HR=0.00,95%CI:0.00~0.21)。结论血清铁调素-25水平在部分人群中对2型糖尿病肾病不良进展具有预测作用。Objective To analyze whether serum hepcidin-25 has a correlation with poor progression of diabetic nephropathy in type 2 diabetes patients.Methods This study was a nested case-control study.Two hundred and twenty patients with type 2 diabetic nephropathy admitted to Xuzhou Central Hospital during April 2015 to June 2019 were involved.Serum hepcidin-25 levels were measured by ELISA,with the poor progression of type 2 diabetic nephropathy(kidney replacement therapy or serum creatinine doubling)as the outcome measure.Multivariate Cox regression analysis was used as the primary analysis method,combined with stratification analysis with glomerular filtration rate as a stratification factor.Results The results of Cox analysis showed that there was no correlation between serum hepcidin-25 levels and poor progression of type 2 diabetic nephropathy(HR=1.18,95%CI:0.97-1.45).However,stratified analysis showed that glomerular filtration rate was an effect modifier of the above relationship:when glomerular filtration rate at a low level[<51.8 mL/(min·1.73 m 2)],there was a positive correlation between serum hepcidin-25 levels and poor progression of type 2 diabetic nephropathy(HR=2.56,95%CI:1.50-4.40),while when the glomerular filtration rate was high,there was a negative correlation between serum hepcidin-25 level and poor progression of type 2 diabetic nephropathy(HR=0.00,95%CI:0.00-0.21).Conclusion Serum hepcidin-25 levels could predicated poor progression of type 2 diabetic nephropathy in specific population.

关 键 词：铁调素-25 2型糖尿病 肾小球滤过率 糖尿病肾病 

分 类 号：R446.11[医药卫生—诊断学]