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作 者:张蕾[1] 胡志德 韩艳秋[1] ZHANG Lei;HU Zhide;HAN Yanqiu(Department of Laboratory Medicine,the Affiliated Hospital of Inner Mongolia Medical University,Hohhot,Inner Mongolia 010050,China)
机构地区:[1]内蒙古医科大学附属医院检验科
出 处:《国际检验医学杂志》2020年第5期611-615,共5页International Journal of Laboratory Medicine
摘 要:目的评价胸腔积液中的干扰素诱导蛋白10(IP-10)对结核性胸膜炎的诊断价值。方法检索PubMed数据库中自2019年6月以来发表的评价IP-10诊断结核性胸膜炎的临床研究文章。采用修订的诊断准确性试验质量评价工具(QUADAS-2)对这些研究的质量进行评价。采用综合层次模型及双变量模型对这些研究的灵敏度和特异度进行合并。结果最终有9项研究727例胸腔积液患者纳入本次meta分析,其中结核性胸膜炎310例,非结核性胸膜炎417例。IP-10诊断结核性胸膜炎的灵敏度为0.83,特异度为0.86,汇总的受试者工作特征曲线的曲线下面积为0.91。亚组分析结果表明采用R&D公司的ELISA试剂盒得到的准确性较高。结论胸腔积液IP-10对结核性胸膜炎的诊断具有较高的价值。Objective To evaluate the diagnostic accuracy of pleural effusionγ-interferon inducible protein 10(IP-10)for tuberculosis pleurisy.Methods Research articles published since June 2019 on evaluating the diagnostic accuracy of pleural effusion IP-10 for tuberculosis were searched in PubMed database.The revised tool for the quality assessment of diagnostic accuracy studies(QUADAS-2)was used to assess the quality of included studies.The hierarchical summary receiver operating characteristic(sROC)curve and bivariate random effects model were used to pool the sensitivity and specificity of eligible studies.Results Nine studies with 727 subjects(310 tuberculosis pleurisy patients and 417 non-tuberculosis pleurisy patients)were enrolled.The pooled sensitivity and specificity of IP-10 were 0.83 and 0.86,respectively.The area under sROC curve was 0.91.Subgroup analysis indicated that the study using ELISA kit of R&D had higher diagnostic accuracy.Conclusion IP-10 in pleural effusion has high diagnostic accuracy for tuberculosis pleurisy.
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