兽用抗菌药物联合用药的PK-PD研究进展  

Progress in PK-PD Research on the Combination of Veterinary Antibacterial Drugs

作　　者：袁园园 黄玲利[1] 郝海红[1] 刘振利[1] 谢长清 袁宗辉[1] 彭大鹏[1] YUAN Yuanyuan;HUANG Lingli;HAO Haihong;LIU Zhenli;XIE Changqing;YUAN Zonghui;PENG Dapeng(National Reference Laboratory of Veterinary Drug Residues,Huazhong Agricultural University,Wuhan 430070,China)

机构地区：[1]华中农业大学国家兽药残留基准实验室

出　　处：《中国畜牧兽医》2020年第1期282-289,共8页China Animal Husbandry & Veterinary Medicine

基　　金：基于可视化技术的磺胺类和甲氧苄啶类双特异分子识别元件与其靶标分子识别机理研究;国家自然科学基金面上项目(31772074)

摘　　要：随着养殖业的迅速发展,兽用抗菌药物的应用越来越广泛,但由于抗菌药物的不合理选择与滥用导致细菌对抗菌药物的耐药率在逐渐提高,几乎所有细菌都获得耐药基因。目前,细菌耐药已成为一个全球性问题,并且临床上,疾病病因复杂,常表现为多种病原菌的继发感染和混合感染,单一用药往往难以有效控制疾病,严重危害养殖业发展。抗菌药物的联合用药可以提升药物的治疗效果,缓解或减少不良反应,降低细菌耐药性发生率,对混合感染或不能进行细菌学诊断的病例,联合用药还可扩大抗菌范围。而药物代谢动力学(PK)与药效学(PD)结合模型可以有效综合药物、机体和致病菌之间的相互关系,为临床提供合理用药方案。因此,作者通过介绍联合用药的优势与问题,抗菌药物PK/PD的分类及PK/PD对联合用药给药方案的优化与指导,总结现阶段兽药抗菌药物联合用药的PK-PD研究进展,以期促进兽医临床抗菌药物的合理使用。With the rapid development of the breeding industry,the application of veterinary antibacterial drugs is more and more extensive.However,due to the unreasonable selection and abuse of antimicrobial drugs,the resistance rate of bacteria to antimicrobial drugs is gradually increasing,and almost all bacteria have acquired resistance genes.At present,bacterial resistance has become a global problem,and clinically,the cause of the disease is complex,often manifested as a variety of pathogens secondary infection and mixed infection,single drug is often difficult to effectively control the disease,seriously endangering the development of aquaculture.The combination of antibiotics can improve the therapeutic effect of drugs,alleviate or reduce adverse reactions,reduce the incidence of bacterial resistance.For cases of mixed infection or unable to carry out bacteriological diagnosis,the combination of antibiotics can also expand the scope of antibacterial.The combination model of PK and PD can effectively integrate the relationship among drugs,organism and pathogenic bacteria,and provide a reasonable medication plan for clinical use.Therefore,by introducing the advantages and problems of the combination of drugs,the classification of PK/PD and the optimization and guidance of PK/PD on the combination of drugs,this paper summarizes the research progress of PK-PD on the combination of veterinary drugs and antibacterial drugs at present,in order to promote the rational use of veterinary clinical antibacterial drugs.

关 键 词：抗菌药物 联合用药 PK/PD 

分 类 号：S859[农业科学—临床兽医学]