MicroRNA影响椎间盘退变过程的研究进展及可发展空间  

Research progress and development space of microRNA in the process of intervertebral disc degeneration

作　　者：胡宝阳 杨学军[2] Hu Baoyang;Yang Xuejun(Inner Mongolia Medical University,Hohhot 010020,Inner Mongolia Autonomous Region,China;Department of Thoracolumbar Spine Surgery,the Second Affiliated Hospital of Inner Mongolia Medical University,Hohhot 010030,Inner Mongolia Autonomous Region,China)

机构地区：[1]内蒙古医科大学,内蒙古自治区呼和浩特市010020 [2]内蒙古医科大学第二附属医院胸腰椎脊柱外科,内蒙古自治区呼和浩特市010030

出　　处：《中国组织工程研究》2020年第21期3372-3378,共7页Chinese Journal of Tissue Engineering Research

基　　金：国家自然科学基金(81960406)，项目负责人：杨学军，项目名称：HMGB1调控因子—miRNA的筛选及对椎间盘软骨终板退变自噬机制的研究~~

摘　　要：背景:在细胞与分子水平上明确MicroRNA(miRNA)在椎间盘退变过程的作用机制,可为早预防或治疗椎间盘退变继发的一系列脊柱疾患提供新的思路。目的:综述miRNA在椎间盘退变原因和机制中的研究现状。方法:应用计算机检索PubMed数据库、万方数据库和中国知网数据库,英文检索词为“miRNA、Intervertebral disc degeneration、Extracellular matrix、Apoptosis、Autophagy、Cartilage endplate、Nucleus pulposus、Fibrous ring”,中文检索词为“miRNA、椎间盘退变、细胞外基质、凋亡、自噬、软骨终板、髓核、纤维环”,最终纳入58篇文章进行综述。结果与结论:miRNA在椎间盘退变过程中的作用已被广泛研究,部分具体机制得到验证;研究多局限于髓核组织,对软骨终板及纤维环报道较少;随着miRNA深入研究,临床方面的研究仍有较大发展空间。BACKGROUND:Full-understanding of the mechanism of microRNA(miRNA)in the process of intervertebral disc degeneration at the cellular and molecular levels can provides new idea for the early prevention or treatment of a series of spinal diseases to intervertebral disc degeneration.OBJECTIVE:To summarize the research status of the role of miRNA in the cause and mechanism of intervertebral disc degeneration.METHODS:A computed-based online retrieval of PubMed,Wanfang and CNKI databases was conducted with the keywords of“miRNA,intervertebral disc degeneration,extracellular matrix,apoptosis,autophagy,cartilage endplate,nucleus pulposus,fibrous ring”in English and Chinese,respectively.Finally 58 eligible articles were included for review.RESULTS AND CONCLUSION:The role of miRNA in intervertebral disc degeneration has been widely studied,and some of the specific mechanisms have been verified.Most of the studies are limited to the nucleus pulposus,and there are few reports on cartilage endplate and annulus fibrosus.With the in-depth study of miRNA,there is still much space for clinical research.

关 键 词：miRNA 椎间盘退变 细胞外基质 凋亡 自噬 软骨终板 髓核 纤维环 

分 类 号：R459.9[医药卫生—治疗学] R681.5[医药卫生—临床医学]