基于数据挖掘的新安王氏内科辨治胃脘痛处方用药规律研究  

Regularity of prescription medication of Xin’an Wang’s internal medicine in treating stomach cramps based on data mining

作　　者：冯烨 王键[3] 杨洪涌[2] 郭锦晨 高兵 程悦 FENG Ye;WANG Jian;YANG Hong-yong;GUO Jin-chen;GAO Bing;CHENG Yue(Guangzhou University of Chinese Medicine,Guangzhou 510405,China;the First Affiliated Hospital of Guangzhou University of Chinese Medicine,Guangzhou 510405,China;Anhui University of Chinese Medicine,Hefei 230038,China)

机构地区：[1]广州中医药大学,广东广州510405 [2]广州中医药大学第一附属医院,广东广州510405 [3]安徽中医药大学,安徽合肥230038

出　　处：《中国中药杂志》2019年第23期5225-5230,共6页China Journal of Chinese Materia Medica

基　　金：“十二五”国家科技支撑计划项目(2012BAI26B00);国家中医药管理局“新安王氏内科流派传承工作室”建设项目(国中医药人教函[2012]228)

摘　　要：该研究运用数据挖掘技术分析新安王氏内科治疗胃脘痛的用药规律,旨在为临床用药提供参考。通过对新安王氏医家(王任之、王仲奇、王乐匋)治疗胃脘痛医案进行归纳研究,用Office 2010对症状、体征、证型及药物进行频数统计,IBM SPSS Modeler 14. 1中Apriori算法、IBM SPSS Statistics 22. 0进行关联规则分析、聚类分析。结果显示,在所收集的310首处方中,共有兼症(包括症状及体征) 322个,涉及药物336种,累计用药4 072频次;症状归属脾胃、肝胆、心系统为多;辨证以肝气犯胃证、饮食伤胃证、脾胃虚寒证为主;常用药物为理气药、化痰药及活血化瘀药;高频药物复杂网络图表明半夏、枳壳、瓜蒌、薤白联系密切;关联分析显示,二项、三项、四项关联规则分别为12,20,17项;聚类分析得出瓜蒌-薤白,半夏-枳壳,九香虫-川楝子等10对药物组合。新安王氏医家认为胃脘痛与肝脾关系密切,气滞、痰凝、血瘀为标,治疗上以"通顺"为第一要务,以疏肝理脾、行气化痰兼以活血化瘀为主要大法,喜用小陷胸汤及瓜蒌薤白半夏汤并随证加减。The study analyzes the medication rules of Xin’an Wang’s internal medicine for treating stomach cramps by data mining technology,in order to provide reference for clinical medication. Through the summarization of the medical cases of stomach cramps treated by Xin’an Wang’s doctors( Wang Ren-zhi,Wang Zhong-qi,Wang Le-tao),statistics was made for the frequency of symptoms,signs,syndromes and drugs in Office 2010. Apriori algorithm in IBM SPSS Modeler 14. 1,and SPSS Statistics 22. 0 were used for association rule analysis and cluster analysis. The results showed that the 310 prescriptions collected involved totally 322 syndromes( including symptoms and signs) and 336 drugs,with the cumulative dose of 4 072 times;the symptoms were correlated to the spleen and stomach,liver and gallbladder,and the heart system;syndrome differentiation was mainly based on liver-Qi invasion of the stomach,diet impairment to the stomach,deficiency of spleen and stomach and cold syndrome;commonly used drugs were Qi regulating drugs,phlegm eliminating drugs and blood circulation promoting and stasis removing drugs;high-frequency drug complex network diagram showed that Pinelliae Rhizoma,Aurantii Fructus,Trichosanthis Fructus,Allii Macrostemonis Bulbus were closely related;the analysis showed 12,20,and 17 two,three,and four association rules;cluster analysis showed 10 pairs of Trichosanthis Fructus-Allii Macrostemonis Bulbus,Pinelliae Rhizoma-Aurantii Fructus,and Aspongopus-Toosendan Fructus drug combinations. According to Xin’ an Wang’s doctors,stomach cramps are closely related to liver and spleen,Qi stagnation,phlegm and blood stasis are the standard.Xin’an Wang’s doctors give the first priority on " deoppilation",focus on soothing the liver and spleen,activating Qi and eliminating phlegm,and promoting blood circulation,and refer to use modified Xiaoxianxiong Decoction and modified Gualou Xiebai Banxia Decoction based on symptoms.

关 键 词：新安医学 王氏内科 胃脘痛 用药规律 关联规则 聚类分析 

分 类 号：TP311.13[自动化与计算机技术—计算机软件与理论] R256.3[自动化与计算机技术—计算机科学与技术]