Ir-catalyzed regiospecific mono-sulfamidation of arylquinazolinones  

作　　者：Yadong Feng Zhenyue Zhang Qi Fu Qiuhong Yao Huabin Huang Jinhai Shen Xiuling Cui 

机构地区：[1]College of Environment and Public Health,Xiamen Huaxia University,Xiamen 361024,China [2]Engineering Research Center of Molecular Medicine of Ministry of Education,Key Laboratory of Fujian Molecular Medicine,Key Laboratory of Xiamen Marine and Gene Drugs,School of Biomedical Sciences,Huaqiao University,Xiamen 361021,China

出　　处：《Chinese Chemical Letters》2020年第1期58-60,共3页中国化学快报（英文版）

基　　金：supported by the National Natural Science Foundation of China (No.21572072);Xiamen Southern Oceanographic Center (No.15PYY052SF01);111 Project (No.BC2018061);the Postgraduates Innovative Fund in Scientific Research of Huaqiao University;the financial support of Scientific Research Foundation of Xiamen Huaxia University (No. HX201807);Outstanding Youth Scientific Research Cultivation Plan in Fujian Province University (2018)

摘　　要：An Ir-catalyzed selective mono-sulfamidation of 2-arylquinazolinones has been achieved with a low catalyst loading under mild conditions.A series of regioselective mono-sulfamided 2-arylquinazolinones were obtained in up to 90%yields.Compared with our previous work of constructing di-sulfamidated 2-arylquinazolinones,the mono-sulfamided products could be obtained selectively by changing the ratio of substrates,the loading of catalyst,acid additive,and reaction time.An Ir-catalyzed selective mono-sulfamidation of 2-arylquinazolinones has been achieved with a low catalyst loading under mild conditions.A series of regioselective mono-sulfamided 2-arylquinazolinones were obtained in up to 90% yields.Compared with our previous work of constructing di-sulfamidated 2-arylquinazolinones,the mono-sulfamided products could be obtained selectively by changing the ratio of substrates,the loading of catalyst,acid additive,and reaction time.

关 键 词：Ir-catalyzed C-H activation Mono-sulfamidation SELECTIVITY Arylquinazolinones 

分 类 号：O621.251[理学—有机化学]