重视对骨质疏松性骨折骨缺损修复材料的研究  

Emphasis on biomaterial research in bone defect repair of osteoporotic fracture

作　　者：王红蕾 屈雪 刘昌胜[1] Wang Honglei;Qu Xue;Liu Changsheng(Engineering Research Center for Biomedical Materials of Ministry of Education,East China University of Science and Technology,Shanghai 200237,China)

机构地区：[1]华东理工大学教育部医用生物材料工程研究中心,上海200237

出　　处：《中华创伤杂志》2020年第1期9-13,共5页Chinese Journal of Trauma

基　　金：国家自然科学基金(51621002,51573047)。

摘　　要：骨质疏松会导致骨量减少、骨强度下降及骨微结构损害,从而增加骨折风险,是困扰老年人健康的常见病。由于骨质疏松骨中成骨细胞的活性下降,破骨细胞活跃,间充质干细胞骨向分化的能力严重受损,导致骨质疏松性骨折后骨愈合速度缓慢,因此骨质疏松性骨折后骨缺损修复是临床面临的一大难题。目前,通过改进植入材料的理化特性和生理活性,原位增强成骨活性或抑制破骨活性来提高骨质疏松性骨折骨缺损修复的效果。笔者主要对骨质疏松性骨折骨缺损修复材料的研究现状、骨缺损的治疗进行阐述,以期对研发用于骨质疏松性骨折骨缺损的修复材料提供参考。Osteoporosis results in decreased bone mass,impaired bone strength and bone microstructure,and thus can easily cause bone fracture.Osteoporosis is one of the common diseases troubling the aging people.Due to the decreased activity of osteoblasts as well as impaired osteogenic differentiation of mesenchymal stem cells,the repair of bone defects accompanied with osteoporosis is very limited.It is a promising way to enhance the healing effect of such bone defect through implanting biomaterials with improved physical and chemical properties as well as elevated bioactivities,since it can mediate the activities of osteogenesis related cells in situ.The author summarizes the popular methods for the modification of biomaterials used for repairing bone defect caused by osteoporotic fractures and provides a prospect in this field,with the aim to provide a reference for the treatment of osteoporotic fractures.

关 键 词：骨质疏松性骨折 组织支架 骨再生 

分 类 号：R6[医药卫生—外科学]