咪达唑仑静脉给药与传统联合方案治疗小儿惊厥持续状态的安全性  

Safety of Intravenous and Traditional Combination of Midazolam in the Treatment of Repeated Pediatric Convulsions

作　　者：冯佩 FENG Pei(Department of Pediatrics,Changping District Hospital,Beijing 102200,China)

机构地区：[1]昌平区医院儿科

出　　处：《医学信息》2020年第2期140-141,共2页Journal of Medical Information

摘　　要：目的观察咪达唑仑静脉给药与传统联合方案治疗小儿惊厥持续状态的安全性。方法选择2018年1月~2019年6月在我院诊治的小儿惊厥持续状态患儿126例,采用随机数字表法分为观察组和对照组,各63例。对照组采用传统地西泮联合苯巴比妥治疗,观察组静脉给予咪达唑仑治疗,比较两组临床治疗总有效率、惊厥控制时间以及治疗前后平均动脉压、心率变化及不良反应发生情况。结果观察组治疗总有效率为96.83%,高于对照组的80.95%(P<0.05);观察组惊厥控制时间为(21.41±3.24)min,短于对照组的(33.02±5.19)min(P<0.05);观察组治疗前后心率、平均动脉压比较,差异无统计学意义(P>0.05);两组心率、平均动脉压均低于治疗前,且观察组高于对照组(P<0.05);对照组不良反应发生率为12.50%,高于观察组的0,差异有统计学意义(P<0.05)。结论静脉给药咪达唑仑与传统联合方案治疗小儿惊厥持续状态疗效确切,可提高临床治疗有效率,且起效快,对心率、血压影响小,用药安全性较好。Objective To observe the safety of midazolam intravenous administration and traditional combination therapy for repeated pediatric convulsions.Methods A total of 126 children with repeated pediatric convulsionsdiagnosed and treated in our hospital from January 2018 to June 2019 were selected and divided into observation group and control group by random number table method,with 63 cases in each group.The control group was treated with traditional diazepam combined with phenobarbital,and the observation group was given intravenous midazolam.The total effective rate of clinical treatment,convulsive control time,changes in mean arterial pressure,heart rate and adverse reactions before and after treatment were compared between the two groups.Results The total effective rate of treatment in the observation group was 96.83%,which was higher than 80.95%in the control group(P<0.05).The seizure control time in the observation group was(21.41±3.24)min,which was shorter than that of the control group(33.02±5.19)min(P<0.05);there was no significant difference in heart rate and mean arterial pressure between the observation group before and after treatment(P>0.05);both groups'heart rate and mean arterial pressure were lower than before treatment,and the observation group was higher than the control group(P<0.05);the incidence of adverse reactions in the control group was 12.50%,and the observation group was 0(P<0.05).Conclusion Intravenous administration of midazolam combined with traditional combined regimen has a definite effect on the repeated pediatric convulsions,which can improve the effectiveness of clinical treatment,and has rapid onset of effects.It has little effect on heart rate and blood pressure,and has better safety.

关 键 词：咪达唑仑 联合方案 小儿惊厥持续状态 安全性 

分 类 号：R720.597[医药卫生—急诊医学]