肾综合征出血热患者DIC评分与F1+2、FPA、FPB的相关性分析  

Correlation analysis of DIC score with F1+2,FPA and FPB in patients with hemorrhagic fever with renal syndrome

作　　者：贾小洲 李燕平 宋红波 刘正稳[1] Jia Xiaozhou;Li Yanping;Song Hongbo;Liu Zhengwen(Department of Infectious Diseases,the First Affiliated Hospital of Xi’an Jiaotong University,Shaanxi Province,Xi'an 710061,China)

机构地区：[1]西安交通大学第一附属医院感染性疾病科,710061 [2]西安交通大学附属西安市第八医院

出　　处：《疑难病杂志》2020年第2期147-150,共4页Chinese Journal of Difficult and Complicated Cases

基　　金：陕西省社会发展科技攻关项目(2016SF-277);西安市科技计划项目(2016045SF/YX01)~~

摘　　要：目的分析肾综合征出血热患者弥散性血管内凝血(DIC)评分与人凝血酶原片段F1+2(F1+2)、纤维蛋白肽A(FPA)、FPB的相关性。方法选取2017年1月-2018年12月西安交通大学附属西安市第八医院感染性疾病科收治肾综合征出血热患者60例,依据DIC评分高低分为A组(DIC评分4~6分,n=19)、B组(DIC评分7~9分,n=27)、C组(DIC评分10~12分,n=14)。观察3组患者发热期、低血压休克期、少尿期、多尿期、恢复期的F1+2、FPA、FPB差异,同时分析DIC评分与5个时期F1+2、FPA、FPB的相关性。结果 A组、B组、C组不同时期血清中F1+2、FPA、FPB均依次增高(F/P=10.835/0.000、14.968/0.000、26.983/0.000、3.737/0.030、6.219/0.004,27.183/0.000、38.867/0.000、38.007/0.000、8.157/0.001、10.725/0.000,21.119/0.000、22.856/0.000、6.370/0.003、7.958/0.001、16.840/0.000)。肾综合征出血热患者DIC评分与发热期、低血压休克期、少尿期、多尿期、恢复期血清中F1+2、FPA、FPB均呈正相关(r/P=0.535/0.000、0.600/0.000、0.582/0.000,0.513/0.000、0.739/0.000、0.601/0.000,0.668/0.000、0.707/0.000、0.410/0.001,0.297/0.021、0.474/0.000、0.439/0.001,0.422/0.001、0.522/0.000、0.640/0.000)。结论肾综合征出血热患者DIC评分与F1+2、FPA、FPB呈正相关,F1+2、FPA、FPB可能与DIC的发生有关。Objective To analyze the correlation between DIC score and human prothrombin fragment F1+2,FPA and FPB.Methods From January 2017 to December 2018,60 patients with HFRS were admitted to the infectious diseases department of the First Affiliated Hospital of Xi an Jiaotong University.According to the DIC score,they were divided into group A(DIC score 4~6,n=19),group B(DIC score 7~9,n=27) and group C(DIC score 10~12,n=14).The differences of F1+2,FPA and FPB in fever period,hypotension shock period,oliguria period,polyuria period and recovery period were observed,and the correlation between DIC score and F1+2,FPA and FPB in five periods was analyzed.Results The serum levels of F1+2,FPA,and FPB in groups A,B,and C in different periods were increased in sequence(F/P=10.835/0.000,14.968/0.000,26.983/0.000,3.737/0.030,6.219/0.004,27.183/0.000,38.867/0.000,38.007/0.000,8.157/0.001,10.725/0.000,21.119/0.000,22.856/0.000,6.370/0.003,7.958/0.001,16.840/0.000).The DIC score of patients with hemorrhagic fever with renal syndrome was positively correlated with F1+2,FPA,and FPB in serum during fever,hypotension shock,oliguria,polyuria,and recovery(r/P=0.535/0.000,0.600/0.000,0.582/0.000,0.513/0.000,0.739/0.000,0.601/0.000,0.668/0.000,0.707/0.000,0.410/0.001,0.297/0.021,0.474/0.000,0.439/0.001,0.422/0.001,0.522/0.000,0.640/0.000).Conclusion DIC score of patients with hemorrhagic fever with renal syndrome is positively correlated with F1+2,FPA and FPB.F1+2,FPA and FPB may be related with the development of DIC.

关 键 词：肾综合征出血热 弥散性血管内凝血 人凝血酶原片段F1+2 纤维蛋白肽A 纤维蛋白肽B 

分 类 号：R512.8[医药卫生—内科学]