真菌中麦角甾醇合成的调控机制  

Regulatory Mechanisms of Ergosterol Biosynthesis in Fungi

作　　者：胡成成 余鹏举 李少杰[1,2] HU Chengcheng;YU Pengju;LI Shaojie(State Key Laboratory of Mycology,Institute of Microbiology,Chinese Academy of Sciences,Beijing 100101,China;University of Chinese Academy of Sciences,Beijing 101408,China)

机构地区：[1]中国科学院微生物研究所真菌学国家重点实验室,北京100101 [2]中国科学院大学,北京101408

出　　处：《菌物研究》2019年第3期138-146,共9页Journal of Fungal Research

基　　金：国家自然科学基金面上项目(31671295)

摘　　要：对细胞中麦角甾醇合成的调控是维持真菌细胞中甾醇含量的关键,文中综述了真菌中麦角甾醇合成的途径,并对其调控机理的研究进展作了重点介绍。甾醇调控元件结合蛋白(SREBP)是真菌中保守的甾醇合成调控因子,能够通过响应麦角甾醇含量的变化来调控甾醇合成基因的表达。但SREBP系统在不同真菌中发生了进化,在酵母亚门中,转录因子Upc2p替代了SREBP,成为了最主要的甾醇合成调控因子。此外,甾醇中间代谢物也被证明可以诱导麦角甾醇合成基因的表达,预示着真菌中存在更为精细的调控机制。The regulation of ergosterol biosynthesis is crucial for the maintenance of ergosterol content in fungi. Here,we reviewed recent researches on the regulation of ergosterol biosynthesis in fungi. Sterol regulatory element binding proteins( SREBPs) are conserved in fungi and play a major role in regulating ergosterol biosynthesis. These proteins respond to ergosterol depletion and regulate expression of ergosterol biosynthetic genes. However,SREBP system is changing during the evolution of fungi,especially in Saccharoymycotina,in which Upc2 p displaces SREBP as the major regulator of ergosterol biosynthesis. In addition,sterol intermediates had been demonstrated to induce the expression of ergosterol biosynthesis genes in recent years,indicating the existence of a more elaborate regulatory mechanism in ergosterol biosynthesis.

关 键 词：真菌 麦角甾醇合成 甾醇调控元件结合蛋白 Upc2p 进化 甾醇中间代谢物 

分 类 号：Q949.32[生物学—植物学] Q946.48